Protection of mice against fatal herpes simplex type 2 infection by liposomes containing muramyl tripeptide

Wayne C. Koff; Stephen D. Showalter; Berge Hampar; Isaiah J. Fidler

doi:10.1126/science.2984772

Protection of mice against fatal herpes simplex type 2 infection by liposomes containing muramyl tripeptide

Wayne C. Koff, Stephen D. Showalter, Berge Hampar, Isaiah J. Fidler

Cancer Biology

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Intravenous administration of liposomes containing muramyl tripeptide phosphatidylethanolamine, a lipophilic derivative of muramyl dipeptide that activates macrophages to a cytolytic state in situ, significantly protected mice against lethal challenge with herpes simplex virus type 2. These findings suggest that the systemic activation of macrophages by liposomes containing an immunomodulator can lead to prophylaxis of severe infections caused by herpesviruses.

Original language	English (US)
Pages (from-to)	495-497
Number of pages	3
Journal	Science
Volume	228
Issue number	4698
DOIs	https://doi.org/10.1126/science.2984772
State	Published - 1985

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title = "Protection of mice against fatal herpes simplex type 2 infection by liposomes containing muramyl tripeptide",

abstract = "Intravenous administration of liposomes containing muramyl tripeptide phosphatidylethanolamine, a lipophilic derivative of muramyl dipeptide that activates macrophages to a cytolytic state in situ, significantly protected mice against lethal challenge with herpes simplex virus type 2. These findings suggest that the systemic activation of macrophages by liposomes containing an immunomodulator can lead to prophylaxis of severe infections caused by herpesviruses.",

author = "Koff, {Wayne C.} and Showalter, {Stephen D.} and Berge Hampar and Fidler, {Isaiah J.}",

year = "1985",

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AU - Koff, Wayne C.

AU - Showalter, Stephen D.

AU - Hampar, Berge

AU - Fidler, Isaiah J.

PY - 1985

Y1 - 1985

N2 - Intravenous administration of liposomes containing muramyl tripeptide phosphatidylethanolamine, a lipophilic derivative of muramyl dipeptide that activates macrophages to a cytolytic state in situ, significantly protected mice against lethal challenge with herpes simplex virus type 2. These findings suggest that the systemic activation of macrophages by liposomes containing an immunomodulator can lead to prophylaxis of severe infections caused by herpesviruses.

AB - Intravenous administration of liposomes containing muramyl tripeptide phosphatidylethanolamine, a lipophilic derivative of muramyl dipeptide that activates macrophages to a cytolytic state in situ, significantly protected mice against lethal challenge with herpes simplex virus type 2. These findings suggest that the systemic activation of macrophages by liposomes containing an immunomodulator can lead to prophylaxis of severe infections caused by herpesviruses.

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Protection of mice against fatal herpes simplex type 2 infection by liposomes containing muramyl tripeptide

Abstract

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