Protein C and Protein S: Causative factor for developing a hemorrhagic infarct in a HbE/Beta thalassemia child

Vineeta Sharma; Arijit Biswas; Bijender Kumar; Renu Saxena

doi:10.1007/s12098-009-0297-5

Protein C and Protein S: Causative factor for developing a hemorrhagic infarct in a HbE/Beta thalassemia child

Vineeta Sharma, Arijit Biswas, Bijender Kumar, Renu Saxena

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A 10-yr-old HbE/Beta thalassemia child who developed subacute to chronic occipitotemporal hemorrhagic infarct with smaller chronic infarct with gliotic changes in the left frontal periventricular white matter. Genetic tests showed that patient was positive for HbE and IVS1-5 mutation and was negative for thrombogenic mutations. Hemorrhagic infarct was confirmed by magnetic resonance imaging study. Antigenic levels of Protein C and Protein S were low. Based on these outcomes, it was concluded that Protein C and Protein S deficiency were the causative factor for developing hemorrhagic infarct in the HbE/ Beta thalassemia Patient.

Original language	English (US)
Pages (from-to)	316-317
Number of pages	2
Journal	Indian Journal of Pediatrics
Volume	77
Issue number	3
DOIs	https://doi.org/10.1007/s12098-009-0297-5
State	Published - Mar 2010
Externally published	Yes

Keywords

Dysgraphia
Dyslexia
Hemianopia
Hemoglobinopathy
Stroke
Thalassemia

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1007/s12098-009-0297-5

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title = "Protein C and Protein S: Causative factor for developing a hemorrhagic infarct in a HbE/Beta thalassemia child",

abstract = "A 10-yr-old HbE/Beta thalassemia child who developed subacute to chronic occipitotemporal hemorrhagic infarct with smaller chronic infarct with gliotic changes in the left frontal periventricular white matter. Genetic tests showed that patient was positive for HbE and IVS1-5 mutation and was negative for thrombogenic mutations. Hemorrhagic infarct was confirmed by magnetic resonance imaging study. Antigenic levels of Protein C and Protein S were low. Based on these outcomes, it was concluded that Protein C and Protein S deficiency were the causative factor for developing hemorrhagic infarct in the HbE/ Beta thalassemia Patient.",

keywords = "Dysgraphia, Dyslexia, Hemianopia, Hemoglobinopathy, Stroke, Thalassemia",

author = "Vineeta Sharma and Arijit Biswas and Bijender Kumar and Renu Saxena",

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doi = "10.1007/s12098-009-0297-5",

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volume = "77",

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T2 - Causative factor for developing a hemorrhagic infarct in a HbE/Beta thalassemia child

AU - Sharma, Vineeta

AU - Biswas, Arijit

AU - Kumar, Bijender

AU - Saxena, Renu

N1 - Funding Information: Role of Funding Source: We are very thankful to ICMR for the financial support.

PY - 2010/3

Y1 - 2010/3

N2 - A 10-yr-old HbE/Beta thalassemia child who developed subacute to chronic occipitotemporal hemorrhagic infarct with smaller chronic infarct with gliotic changes in the left frontal periventricular white matter. Genetic tests showed that patient was positive for HbE and IVS1-5 mutation and was negative for thrombogenic mutations. Hemorrhagic infarct was confirmed by magnetic resonance imaging study. Antigenic levels of Protein C and Protein S were low. Based on these outcomes, it was concluded that Protein C and Protein S deficiency were the causative factor for developing hemorrhagic infarct in the HbE/ Beta thalassemia Patient.

AB - A 10-yr-old HbE/Beta thalassemia child who developed subacute to chronic occipitotemporal hemorrhagic infarct with smaller chronic infarct with gliotic changes in the left frontal periventricular white matter. Genetic tests showed that patient was positive for HbE and IVS1-5 mutation and was negative for thrombogenic mutations. Hemorrhagic infarct was confirmed by magnetic resonance imaging study. Antigenic levels of Protein C and Protein S were low. Based on these outcomes, it was concluded that Protein C and Protein S deficiency were the causative factor for developing hemorrhagic infarct in the HbE/ Beta thalassemia Patient.

KW - Dysgraphia

KW - Dyslexia

KW - Hemianopia

KW - Hemoglobinopathy

KW - Stroke

KW - Thalassemia

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Protein C and Protein S: Causative factor for developing a hemorrhagic infarct in a HbE/Beta thalassemia child

Abstract

Keywords

ASJC Scopus subject areas

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