Protein folding: Then and now

Yiwen Chen; Feng Ding; Huifen Nie; Adrian W. Serohijos; Shantanu Sharma; Kyle C. Wilcox; Shuangye Yin; Nikolay V. Dokholyan

doi:10.1016/j.abb.2007.05.014

Protein folding: Then and now

Yiwen Chen, Feng Ding, Huifen Nie, Adrian W. Serohijos, Shantanu Sharma, Kyle C. Wilcox, Shuangye Yin, Nikolay V. Dokholyan

Research output: Contribution to journal › Review article › peer-review

81 Scopus citations

Abstract

Over the past three decades the protein folding field has undergone monumental changes. Originally a purely academic question, how a protein folds has now become vital in understanding diseases and our abilities to rationally manipulate cellular life by engineering protein folding pathways. We review and contrast past and recent developments in the protein folding field. Specifically, we discuss the progress in our understanding of protein folding thermodynamics and kinetics, the properties of evasive intermediates, and unfolded states. We also discuss how some abnormalities in protein folding lead to protein aggregation and human diseases.

Original language	English (US)
Pages (from-to)	4-19
Number of pages	16
Journal	Archives of Biochemistry and Biophysics
Volume	469
Issue number	1
DOIs	https://doi.org/10.1016/j.abb.2007.05.014
State	Published - Jan 1 2008
Externally published	Yes

Keywords

Aggregation
Discrete molecular dynamics (DMD)
Folding kinetics
Misfolding
Protein folding
Protein thermodynamics

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology

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10.1016/j.abb.2007.05.014

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title = "Protein folding: Then and now",

abstract = "Over the past three decades the protein folding field has undergone monumental changes. Originally a purely academic question, how a protein folds has now become vital in understanding diseases and our abilities to rationally manipulate cellular life by engineering protein folding pathways. We review and contrast past and recent developments in the protein folding field. Specifically, we discuss the progress in our understanding of protein folding thermodynamics and kinetics, the properties of evasive intermediates, and unfolded states. We also discuss how some abnormalities in protein folding lead to protein aggregation and human diseases.",

keywords = "Aggregation, Discrete molecular dynamics (DMD), Folding kinetics, Misfolding, Protein folding, Protein thermodynamics",

author = "Yiwen Chen and Feng Ding and Huifen Nie and Serohijos, {Adrian W.} and Shantanu Sharma and Wilcox, {Kyle C.} and Shuangye Yin and Dokholyan, {Nikolay V.}",

note = "Funding Information: We thank Oana Lungu for reading the manuscript. This work was supported by the American Heart Association Grant No. 0665361U, the North Carolina Biotechnology Center Grant No. 2006-MRG-1107, Cystic Fibrosis Foundation Grant DOKHOL07I0, and the National Institutes of Health Grants R01GM080742-01 and R01CA084480-07.",

year = "2008",

month = jan,

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doi = "10.1016/j.abb.2007.05.014",

language = "English (US)",

volume = "469",

pages = "4--19",

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TY - JOUR

T1 - Protein folding

T2 - Then and now

AU - Chen, Yiwen

AU - Ding, Feng

AU - Nie, Huifen

AU - Serohijos, Adrian W.

AU - Sharma, Shantanu

AU - Wilcox, Kyle C.

AU - Yin, Shuangye

AU - Dokholyan, Nikolay V.

N1 - Funding Information: We thank Oana Lungu for reading the manuscript. This work was supported by the American Heart Association Grant No. 0665361U, the North Carolina Biotechnology Center Grant No. 2006-MRG-1107, Cystic Fibrosis Foundation Grant DOKHOL07I0, and the National Institutes of Health Grants R01GM080742-01 and R01CA084480-07.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Over the past three decades the protein folding field has undergone monumental changes. Originally a purely academic question, how a protein folds has now become vital in understanding diseases and our abilities to rationally manipulate cellular life by engineering protein folding pathways. We review and contrast past and recent developments in the protein folding field. Specifically, we discuss the progress in our understanding of protein folding thermodynamics and kinetics, the properties of evasive intermediates, and unfolded states. We also discuss how some abnormalities in protein folding lead to protein aggregation and human diseases.

AB - Over the past three decades the protein folding field has undergone monumental changes. Originally a purely academic question, how a protein folds has now become vital in understanding diseases and our abilities to rationally manipulate cellular life by engineering protein folding pathways. We review and contrast past and recent developments in the protein folding field. Specifically, we discuss the progress in our understanding of protein folding thermodynamics and kinetics, the properties of evasive intermediates, and unfolded states. We also discuss how some abnormalities in protein folding lead to protein aggregation and human diseases.

KW - Aggregation

KW - Discrete molecular dynamics (DMD)

KW - Folding kinetics

KW - Misfolding

KW - Protein folding

KW - Protein thermodynamics

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DO - 10.1016/j.abb.2007.05.014

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SN - 0003-9861

VL - 469

SP - 4

EP - 19

JO - Archives of Biochemistry and Biophysics

JF - Archives of Biochemistry and Biophysics

IS - 1

ER -

Protein folding: Then and now

Abstract

Keywords

ASJC Scopus subject areas

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