Protein methylation and DNA repair

Aimee N. Lake; Mark T. Bedford

doi:10.1016/j.mrfmmm.2006.09.010

Protein methylation and DNA repair

Aimee N. Lake, Mark T. Bedford

Epigenetics & Molecular Carcinogenesis

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

DNA is under constant attack from intracellular and external mutagens. Sites of DNA damage need to be pinpointed so that the DNA repair machinery can be mobilized to the proper location. The identification of damaged sites, recruitment of repair factors, and assembly of repair "factories" is orchestrated by posttranslational modifications (PTMs). These PTMs include phosphorylation, ubiquitination, sumoylation, acetylation, and methylation. Here we discuss recent data surrounding the roles of arginine and lysine methylation in DNA repair processes.

Original language	English (US)
Pages (from-to)	91-101
Number of pages	11
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	618
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mrfmmm.2006.09.010
State	Published - May 1 2007

Keywords

53BP1
Arginine methylation
Chromo domain
Lysine methylation
P53
PHF20
Tudor domain

ASJC Scopus subject areas

Health, Toxicology and Mutagenesis
Molecular Biology

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10.1016/j.mrfmmm.2006.09.010

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abstract = "DNA is under constant attack from intracellular and external mutagens. Sites of DNA damage need to be pinpointed so that the DNA repair machinery can be mobilized to the proper location. The identification of damaged sites, recruitment of repair factors, and assembly of repair {"}factories{"} is orchestrated by posttranslational modifications (PTMs). These PTMs include phosphorylation, ubiquitination, sumoylation, acetylation, and methylation. Here we discuss recent data surrounding the roles of arginine and lysine methylation in DNA repair processes.",

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AU - Bedford, Mark T.

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AB - DNA is under constant attack from intracellular and external mutagens. Sites of DNA damage need to be pinpointed so that the DNA repair machinery can be mobilized to the proper location. The identification of damaged sites, recruitment of repair factors, and assembly of repair "factories" is orchestrated by posttranslational modifications (PTMs). These PTMs include phosphorylation, ubiquitination, sumoylation, acetylation, and methylation. Here we discuss recent data surrounding the roles of arginine and lysine methylation in DNA repair processes.

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KW - Chromo domain

KW - Lysine methylation

KW - P53

KW - PHF20

KW - Tudor domain

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Protein methylation and DNA repair

Abstract

Keywords

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