TY - JOUR
T1 - Protein mislocalization
T2 - Mechanisms, functions and clinical applications in cancer
AU - Wang, Xiaohong
AU - Li, Shulin
N1 - Funding Information:
We would like to thank Ms. Elizabeth L Hess from the Department of Scientific Publications, The University of Texas MD Anderson Cancer Center, for her critical review and editing of this manuscript. This study was supported by National Cancer Institute grants RO1CA098928 and RO1CA142855 .
PY - 2014/8
Y1 - 2014/8
N2 - The changes from normal cells to cancer cells are primarily regulated by genome instability, which foster hallmark functions of cancer through multiple mechanisms including protein mislocalization. Mislocalization of these proteins, including oncoproteins, tumor suppressors, and other cancer-related proteins, can interfere with normal cellular function and cooperatively drive tumor development and metastasis. This review describes the cancer-related effects of protein subcellular mislocalization, the related mislocalization mechanisms, and the potential application of this knowledge to cancer diagnosis, prognosis, and therapy.
AB - The changes from normal cells to cancer cells are primarily regulated by genome instability, which foster hallmark functions of cancer through multiple mechanisms including protein mislocalization. Mislocalization of these proteins, including oncoproteins, tumor suppressors, and other cancer-related proteins, can interfere with normal cellular function and cooperatively drive tumor development and metastasis. This review describes the cancer-related effects of protein subcellular mislocalization, the related mislocalization mechanisms, and the potential application of this knowledge to cancer diagnosis, prognosis, and therapy.
KW - Cancer
KW - Oncogene
KW - Subcellular localization
KW - Tumor suppressor
UR - http://www.scopus.com/inward/record.url?scp=84898965370&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84898965370&partnerID=8YFLogxK
U2 - 10.1016/j.bbcan.2014.03.006
DO - 10.1016/j.bbcan.2014.03.006
M3 - Review article
C2 - 24709009
AN - SCOPUS:84898965370
SN - 0304-419X
VL - 1846
SP - 13
EP - 25
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
IS - 1
ER -