Proton magnetic resonance spectroscopic studies of hypertrophied muscle: Effect of botulinum toxin treatment

Ponnada A. Narayana; John M. Slopis; Edward F. Jackson; Joseph Jankovic; Ian J. Butler

doi:10.1097/00004424-199101000-00011

Proton magnetic resonance spectroscopic studies of hypertrophied muscle: Effect of botulinum toxin treatment

Ponnada A. Narayana, John M. Slopis, Edward F. Jackson, Joseph Jankovic, Ian J. Butler

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

In vivo image-guided localized proton magnetic resonance spectroscopy (MRS) studies have been performed in a patient with hypertrophied tibialis anterior (TA) muscle and following two injections of botulinum toxin into the affected muscle. Prior to treatment, lipid levels in hypertrophied muscle were found to be low compared to normal. Lipid levels were observed to approach control levels after the second injection. Three months following treatment the trend in exercise-induced changes in lipids was observed to be similar between the hypertrophied and normal TA muscle. This preliminary report demonstrates the potential clinical utility of MRS in evaluating patient response to medical treatment.

Original language	English (US)
Pages (from-to)	58-64
Number of pages	7
Journal	Investigative radiology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1097/00004424-199101000-00011
State	Published - Jan 1991

Keywords

Botulinum toxin
Hypertrophied
Magnetic resonance spectroscopy
Muscle
Muscle lipids
Tibialis anterior

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1097/00004424-199101000-00011

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abstract = "In vivo image-guided localized proton magnetic resonance spectroscopy (MRS) studies have been performed in a patient with hypertrophied tibialis anterior (TA) muscle and following two injections of botulinum toxin into the affected muscle. Prior to treatment, lipid levels in hypertrophied muscle were found to be low compared to normal. Lipid levels were observed to approach control levels after the second injection. Three months following treatment the trend in exercise-induced changes in lipids was observed to be similar between the hypertrophied and normal TA muscle. This preliminary report demonstrates the potential clinical utility of MRS in evaluating patient response to medical treatment.",

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AU - Narayana, Ponnada A.

AU - Slopis, John M.

AU - Jackson, Edward F.

AU - Jankovic, Joseph

AU - Butler, Ian J.

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AB - In vivo image-guided localized proton magnetic resonance spectroscopy (MRS) studies have been performed in a patient with hypertrophied tibialis anterior (TA) muscle and following two injections of botulinum toxin into the affected muscle. Prior to treatment, lipid levels in hypertrophied muscle were found to be low compared to normal. Lipid levels were observed to approach control levels after the second injection. Three months following treatment the trend in exercise-induced changes in lipids was observed to be similar between the hypertrophied and normal TA muscle. This preliminary report demonstrates the potential clinical utility of MRS in evaluating patient response to medical treatment.

KW - Botulinum toxin

KW - Hypertrophied

KW - Magnetic resonance spectroscopy

KW - Muscle

KW - Muscle lipids

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Proton magnetic resonance spectroscopic studies of hypertrophied muscle: Effect of botulinum toxin treatment

Abstract

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