Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus

Silvia Lodeiro; Quanbo Xiong; William K. Wilson; Yulia Ivanova; Mckenzie L. Smith; Gregory S. May; Seiichi P.T. Matsuda

doi:10.1021/ol802696a

Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus

Silvia Lodeiro, Quanbo Xiong, William K. Wilson, Yulia Ivanova, Mckenzie L. Smith, Gregory S. May, Seiichi P.T. Matsuda

Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Details of the fungal biosynthetic pathway to helvolic acid and other fusidane antibiotics remain obscure. During product characterization of oxidosqualene cyclases in Aspergillus fumigatus, we found the long-sought cyclase that makes (17Z)-protosta-17(20),24-dien-3β-ol, the precursor of helvolic acid. We then identified a gene cluster encoding the pathway to helvolic acid, which is controlled by a transcription regulator (LaeA) associated with fungal virulence. Evidence regarding the evolutionary origin and taxonomic distribution of fusidane biosynthesis is also presented.

Original language	English (US)
Pages (from-to)	1241-1244
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	6
DOIs	https://doi.org/10.1021/ol802696a
State	Published - Mar 19 2009

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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AU - Lodeiro, Silvia

AU - Xiong, Quanbo

AU - Wilson, William K.

AU - Ivanova, Yulia

AU - Smith, Mckenzie L.

AU - May, Gregory S.

AU - Matsuda, Seiichi P.T.

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Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus

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