TY - JOUR
T1 - Psychological states, serum markers and survival
T2 - associations and predictors of survival in patients with renal cell carcinoma
AU - Prinsloo, Sarah
AU - Wei, Qi
AU - Scott, Shellie M.
AU - Tannir, Nizar
AU - Jonasch, Eric
AU - Pisters, Louis
AU - Cohen, Lorenzo
N1 - Publisher Copyright:
© 2014, Springer Science+Business Media New York.
PY - 2014/2
Y1 - 2014/2
N2 - This study sought to determine if there was an association between prognostic-based serum biomarkers, survival, and psychosocial factors in patients with metastatic renal cell carcinoma. Associations were found between psychosocial factors and biomarker levels (hemoglobin with depressive symptoms (r = −0.29), positive affect (r = 0.30), social support (r = 0.19), and perceived stress (r = −0.27); albumin with depressive symptoms (r = −0.19), positive affect (r = 0.22), and social support (r = 0.20); alkaline phosphatase with depressive symptoms (r = 0.21), all p values <0.05. After adjustment for disease-related risk factors, only the associations between positive affect and perceived stress with hemoglobin remained significant (p’s < 0.05). Positive affect (HR = 0.90; 95 % CI = 0.83, 0.97; p = 0.009) and depressive symptom total scores (HR = 1.03; 95 % CI = 1.01, 1.06; p = 0.013), and alkaline phosphatase (HR 2.72; 95 % CI = 1.41, 5.24; p = 0.003) were associated with survival. This study suggests that measures of positive and negative psychological outlook may contribute differently to health, well-being, and survival.
AB - This study sought to determine if there was an association between prognostic-based serum biomarkers, survival, and psychosocial factors in patients with metastatic renal cell carcinoma. Associations were found between psychosocial factors and biomarker levels (hemoglobin with depressive symptoms (r = −0.29), positive affect (r = 0.30), social support (r = 0.19), and perceived stress (r = −0.27); albumin with depressive symptoms (r = −0.19), positive affect (r = 0.22), and social support (r = 0.20); alkaline phosphatase with depressive symptoms (r = 0.21), all p values <0.05. After adjustment for disease-related risk factors, only the associations between positive affect and perceived stress with hemoglobin remained significant (p’s < 0.05). Positive affect (HR = 0.90; 95 % CI = 0.83, 0.97; p = 0.009) and depressive symptom total scores (HR = 1.03; 95 % CI = 1.01, 1.06; p = 0.013), and alkaline phosphatase (HR 2.72; 95 % CI = 1.41, 5.24; p = 0.003) were associated with survival. This study suggests that measures of positive and negative psychological outlook may contribute differently to health, well-being, and survival.
KW - Biopsychosocial
KW - Cancer
KW - Depression
KW - Positive affect
KW - Positive psychology
KW - Survival
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U2 - 10.1007/s10865-014-9578-1
DO - 10.1007/s10865-014-9578-1
M3 - Article
C2 - 24935017
AN - SCOPUS:84939892952
SN - 0160-7715
VL - 38
SP - 48
EP - 56
JO - Journal of Behavioral Medicine
JF - Journal of Behavioral Medicine
IS - 1
ER -