PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET

Hongmei Dong; Wan Lin; Liang Du; Zhimeng Yao; Feifei Li; Shuanglong Chen; Yiteng Huang; Hongzheng Ren; Yichen Luo; Songwang Cai; Yexi Chen; Hui Tang; Xiaofu Qiu; Yunlong Pan; Xingxu Huang; Dianzheng Zhang; Shegan Gao; Sai Ching Jim Yeung; Hao Zhang

doi:10.1016/j.canlet.2023.216283

PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET

Hongmei Dong, Wan Lin, Liang Du, Zhimeng Yao, Feifei Li, Shuanglong Chen, Yiteng Huang, Hongzheng Ren, Yichen Luo, Songwang Cai, Yexi Chen, Hui Tang, Xiaofu Qiu, Yunlong Pan, Xingxu Huang, Dianzheng Zhang, Shegan Gao, Sai Ching Jim Yeung, Hao Zhang

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1 Scopus citations

Abstract

Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PTPRO due to promoter hypermethylation is frequently linked to malignancies. In this study, we used cellular and animal models, and patient samples to demonstrate that PTPRO can suppress the metastasis of esophageal squamous cell carcinoma (ESCC). Mechanistically, PTPRO can inhibit MET-mediated metastasis by dephosphorylating Y1234/1235 in the kinase activation loop of MET. Patients with PTPRO^low/p-MET^high had significantly poor prognosis, suggesting that PTPRO^low/p-MET^high can serve as an independent prognostic factor for patients with ESCC.

Original language	English (US)
Article number	216283
Journal	Cancer Letters
Volume	567
DOIs	https://doi.org/10.1016/j.canlet.2023.216283
State	Published - Jul 28 2023

Keywords

Esophageal squamous cell carcinoma
MET
Metastasis
PTPRO
Tyrosine phosphatase

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2023.216283

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@article{6eb871fb3d534d24b047172ae796c817,

title = "PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET",

abstract = "Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PTPRO due to promoter hypermethylation is frequently linked to malignancies. In this study, we used cellular and animal models, and patient samples to demonstrate that PTPRO can suppress the metastasis of esophageal squamous cell carcinoma (ESCC). Mechanistically, PTPRO can inhibit MET-mediated metastasis by dephosphorylating Y1234/1235 in the kinase activation loop of MET. Patients with PTPROlow/p-METhigh had significantly poor prognosis, suggesting that PTPROlow/p-METhigh can serve as an independent prognostic factor for patients with ESCC.",

keywords = "Esophageal squamous cell carcinoma, MET, Metastasis, PTPRO, Tyrosine phosphatase",

author = "Hongmei Dong and Wan Lin and Liang Du and Zhimeng Yao and Feifei Li and Shuanglong Chen and Yiteng Huang and Hongzheng Ren and Yichen Luo and Songwang Cai and Yexi Chen and Hui Tang and Xiaofu Qiu and Yunlong Pan and Xingxu Huang and Dianzheng Zhang and Shegan Gao and Yeung, {Sai Ching Jim} and Hao Zhang",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier B.V.",

year = "2023",

month = jul,

day = "28",

doi = "10.1016/j.canlet.2023.216283",

language = "English (US)",

volume = "567",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

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TY - JOUR

T1 - PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET

AU - Dong, Hongmei

AU - Lin, Wan

AU - Du, Liang

AU - Yao, Zhimeng

AU - Li, Feifei

AU - Chen, Shuanglong

AU - Huang, Yiteng

AU - Ren, Hongzheng

AU - Luo, Yichen

AU - Cai, Songwang

AU - Chen, Yexi

AU - Tang, Hui

AU - Qiu, Xiaofu

AU - Pan, Yunlong

AU - Huang, Xingxu

AU - Zhang, Dianzheng

AU - Gao, Shegan

AU - Yeung, Sai Ching Jim

AU - Zhang, Hao

PY - 2023/7/28

Y1 - 2023/7/28

N2 - Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PTPRO due to promoter hypermethylation is frequently linked to malignancies. In this study, we used cellular and animal models, and patient samples to demonstrate that PTPRO can suppress the metastasis of esophageal squamous cell carcinoma (ESCC). Mechanistically, PTPRO can inhibit MET-mediated metastasis by dephosphorylating Y1234/1235 in the kinase activation loop of MET. Patients with PTPROlow/p-METhigh had significantly poor prognosis, suggesting that PTPROlow/p-METhigh can serve as an independent prognostic factor for patients with ESCC.

AB - Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PTPRO due to promoter hypermethylation is frequently linked to malignancies. In this study, we used cellular and animal models, and patient samples to demonstrate that PTPRO can suppress the metastasis of esophageal squamous cell carcinoma (ESCC). Mechanistically, PTPRO can inhibit MET-mediated metastasis by dephosphorylating Y1234/1235 in the kinase activation loop of MET. Patients with PTPROlow/p-METhigh had significantly poor prognosis, suggesting that PTPROlow/p-METhigh can serve as an independent prognostic factor for patients with ESCC.

KW - Esophageal squamous cell carcinoma

KW - MET

KW - Metastasis

KW - PTPRO

KW - Tyrosine phosphatase

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U2 - 10.1016/j.canlet.2023.216283

DO - 10.1016/j.canlet.2023.216283

M3 - Article

C2 - 37331584

AN - SCOPUS:85163402621

SN - 0304-3835

VL - 567

JO - Cancer Letters

JF - Cancer Letters

M1 - 216283

ER -

PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET

Abstract

Keywords

ASJC Scopus subject areas

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