TY - JOUR
T1 - Pulmonary artery sarcoma
T2 - A clinicopathologic and immunohistochemical study of 12 cases
AU - Huo, Lei
AU - Moran, Cesar A.
AU - Fuller, Gregory N.
AU - Gladish, Gregory
AU - Suster, Saul
PY - 2006/3
Y1 - 2006/3
N2 - We report 12 cases of pulmonary artery sarcoma. The mean age at diagnosis was 48.4 years. Based on histomorphologic features and immunohistochemical findings, 2 tumors were classified as rhabdomyosarcoma, 4 as leiomyosarcoma, 1 as osteogenic sarcoma, 1 as angiosarcoma, and 4 as high-grade sarcoma. All patients underwent surgery. In addition, 7 patients received neoadjuvant or adjuvant therapy. Five patients died 3 to 23 months after surgery. Three patients were still alive at 8, 27, and 68 months at last follow-up. Another 3 patients were alive at 2, 15, and 40 months and then lost to follow-up. The 2 patients with the longest survival (40 months and 68 months) had a diagnosis of leiomyosarcoma. Both patients with rhabdomyosarcoma died at 3 months after surgery. Pulmonary artery sarcoma is an uncommon entity with a poor prognosis. The role of early diagnosis, histologic classification, surgical treatment, and adjuvant therapy in patient outcome is discussed.
AB - We report 12 cases of pulmonary artery sarcoma. The mean age at diagnosis was 48.4 years. Based on histomorphologic features and immunohistochemical findings, 2 tumors were classified as rhabdomyosarcoma, 4 as leiomyosarcoma, 1 as osteogenic sarcoma, 1 as angiosarcoma, and 4 as high-grade sarcoma. All patients underwent surgery. In addition, 7 patients received neoadjuvant or adjuvant therapy. Five patients died 3 to 23 months after surgery. Three patients were still alive at 8, 27, and 68 months at last follow-up. Another 3 patients were alive at 2, 15, and 40 months and then lost to follow-up. The 2 patients with the longest survival (40 months and 68 months) had a diagnosis of leiomyosarcoma. Both patients with rhabdomyosarcoma died at 3 months after surgery. Pulmonary artery sarcoma is an uncommon entity with a poor prognosis. The role of early diagnosis, histologic classification, surgical treatment, and adjuvant therapy in patient outcome is discussed.
KW - Clinicopathologic
KW - Histologic classification
KW - Immunohistochemistry
KW - Intimal sarcoma
KW - Prognosis
KW - Pulmonary artery
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U2 - 10.1309/9H8RHUV1JL1WE0QF
DO - 10.1309/9H8RHUV1JL1WE0QF
M3 - Article
C2 - 16613346
AN - SCOPUS:33644638805
SN - 0002-9173
VL - 125
SP - 419
EP - 424
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 3
ER -