Pulmonary well-differentiated fetal adenocarcinoma with platelet-derived growth factor receptor (PDGFR)α expression

Can Qiao Luo; Sai Ching J. Yeung; Zhen Guo Liu; Jun Meng; Fo Tian Zhong; Chao Cheng

doi:10.4161/cbt.22253

Pulmonary well-differentiated fetal adenocarcinoma with platelet-derived growth factor receptor (PDGFR)α expression

Can Qiao Luo, Sai Ching J. Yeung, Zhen Guo Liu, Jun Meng, Fo Tian Zhong, Chao Cheng

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Well-differentiated fetal adenocarcinoma (WDFA) is a rare pulmonary malignancy. Biomarkers of tumor biology has rarely been studied in WDFA. Here, we report two WDFA patients. Both patients had blood-streaked sputum or mild hemoptysis at presentation. They underwent lobectomy and systematic mediastinal lymphadenectomy. Expression of PDGFRα on the plasma membrane was demonstrated by immunohistochemistry (IH C) in the resected tumor specimens. Further IH C examination showed intense immunostaining of β-catenin in both patients but negative staining for TP53, CEA, CD56, EGFR, CK5/6, HE R2, S-100, ER, PR, BCL2, and NSE . Both patients had no recurrence to date after more than 3 years of follow up. Herein, we reviewed this rare disease with special emphasis on the clinico-pathological features, treatment and potential role of PDGFRα.

Original language	English (US)
Pages (from-to)	1384-1389
Number of pages	6
Journal	Cancer Biology and Therapy
Volume	13
Issue number	14
DOIs	https://doi.org/10.4161/cbt.22253
State	Published - Dec 2012

Keywords

Lung cancer
PDGFRα
Surgery
WDFA
Well-differentiated fetal adenocarcinoma
β-catenin

ASJC Scopus subject areas

Molecular Medicine
Oncology
Pharmacology
Cancer Research

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10.4161/cbt.22253

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title = "Pulmonary well-differentiated fetal adenocarcinoma with platelet-derived growth factor receptor (PDGFR)α expression",

abstract = "Well-differentiated fetal adenocarcinoma (WDFA) is a rare pulmonary malignancy. Biomarkers of tumor biology has rarely been studied in WDFA. Here, we report two WDFA patients. Both patients had blood-streaked sputum or mild hemoptysis at presentation. They underwent lobectomy and systematic mediastinal lymphadenectomy. Expression of PDGFRα on the plasma membrane was demonstrated by immunohistochemistry (IH C) in the resected tumor specimens. Further IH C examination showed intense immunostaining of β-catenin in both patients but negative staining for TP53, CEA, CD56, EGFR, CK5/6, HE R2, S-100, ER, PR, BCL2, and NSE . Both patients had no recurrence to date after more than 3 years of follow up. Herein, we reviewed this rare disease with special emphasis on the clinico-pathological features, treatment and potential role of PDGFRα.",

keywords = "Lung cancer, PDGFRα, Surgery, WDFA, Well-differentiated fetal adenocarcinoma, β-catenin",

author = "Luo, {Can Qiao} and Yeung, {Sai Ching J.} and Liu, {Zhen Guo} and Jun Meng and Zhong, {Fo Tian} and Chao Cheng",

note = "Funding Information: No potential conflicts of interest were disclosed. The work was supported by grants from China National Natural Sciences Foundation (0801136 to C.C.) and (81171125 to C.C.) and the Research and Development Program of Sun Yat-sen University (10YKPY09 to C.C.).",

year = "2012",

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doi = "10.4161/cbt.22253",

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AU - Luo, Can Qiao

AU - Yeung, Sai Ching J.

AU - Liu, Zhen Guo

AU - Meng, Jun

AU - Zhong, Fo Tian

AU - Cheng, Chao

N1 - Funding Information: No potential conflicts of interest were disclosed. The work was supported by grants from China National Natural Sciences Foundation (0801136 to C.C.) and (81171125 to C.C.) and the Research and Development Program of Sun Yat-sen University (10YKPY09 to C.C.).

PY - 2012/12

Y1 - 2012/12

N2 - Well-differentiated fetal adenocarcinoma (WDFA) is a rare pulmonary malignancy. Biomarkers of tumor biology has rarely been studied in WDFA. Here, we report two WDFA patients. Both patients had blood-streaked sputum or mild hemoptysis at presentation. They underwent lobectomy and systematic mediastinal lymphadenectomy. Expression of PDGFRα on the plasma membrane was demonstrated by immunohistochemistry (IH C) in the resected tumor specimens. Further IH C examination showed intense immunostaining of β-catenin in both patients but negative staining for TP53, CEA, CD56, EGFR, CK5/6, HE R2, S-100, ER, PR, BCL2, and NSE . Both patients had no recurrence to date after more than 3 years of follow up. Herein, we reviewed this rare disease with special emphasis on the clinico-pathological features, treatment and potential role of PDGFRα.

AB - Well-differentiated fetal adenocarcinoma (WDFA) is a rare pulmonary malignancy. Biomarkers of tumor biology has rarely been studied in WDFA. Here, we report two WDFA patients. Both patients had blood-streaked sputum or mild hemoptysis at presentation. They underwent lobectomy and systematic mediastinal lymphadenectomy. Expression of PDGFRα on the plasma membrane was demonstrated by immunohistochemistry (IH C) in the resected tumor specimens. Further IH C examination showed intense immunostaining of β-catenin in both patients but negative staining for TP53, CEA, CD56, EGFR, CK5/6, HE R2, S-100, ER, PR, BCL2, and NSE . Both patients had no recurrence to date after more than 3 years of follow up. Herein, we reviewed this rare disease with special emphasis on the clinico-pathological features, treatment and potential role of PDGFRα.

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Pulmonary well-differentiated fetal adenocarcinoma with platelet-derived growth factor receptor (PDGFR)α expression

Abstract

Keywords

ASJC Scopus subject areas

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