Pulse Cytophotometric Analysis of Cell Cycle Perturbation with Bleomycin in Vitro

Barthel Barlogie; Benjamin Drewinko; Johannes Schumann

Pulse Cytophotometric Analysis of Cell Cycle Perturbation with Bleomycin in Vitro

Barthel Barlogie, Benjamin Drewinko, Johannes Schumann

Leukemia

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Abstract

The kinetic response of a human lymphoma cell line to bleomycin has been analyzed, using an ICP-11 pulse cytophotometer. Bleomycin induced a delay of the cell-cycle traverse in G₂ phase, the extent and recovery of which depended on drug concentration, exposure time, and cell cycle stage where treatment was applied. Different phase sensitivity for lethal damage (G₂ phase) and kinetic response (early S phase) were documented. Recovery from G ₂ block did not predict for unimpaired reproductive capacity.

Original language	English (US)
Pages (from-to)	1182-1187
Number of pages	6
Journal	Cancer Research
Volume	36
Issue number	3
State	Published - Mar 1976

ASJC Scopus subject areas

Cancer Research
Oncology

Cite this

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abstract = "The kinetic response of a human lymphoma cell line to bleomycin has been analyzed, using an ICP-11 pulse cytophotometer. Bleomycin induced a delay of the cell-cycle traverse in G2 phase, the extent and recovery of which depended on drug concentration, exposure time, and cell cycle stage where treatment was applied. Different phase sensitivity for lethal damage (G2 phase) and kinetic response (early S phase) were documented. Recovery from G 2 block did not predict for unimpaired reproductive capacity.",

author = "Barthel Barlogie and Benjamin Drewinko and Johannes Schumann",

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N2 - The kinetic response of a human lymphoma cell line to bleomycin has been analyzed, using an ICP-11 pulse cytophotometer. Bleomycin induced a delay of the cell-cycle traverse in G2 phase, the extent and recovery of which depended on drug concentration, exposure time, and cell cycle stage where treatment was applied. Different phase sensitivity for lethal damage (G2 phase) and kinetic response (early S phase) were documented. Recovery from G 2 block did not predict for unimpaired reproductive capacity.

AB - The kinetic response of a human lymphoma cell line to bleomycin has been analyzed, using an ICP-11 pulse cytophotometer. Bleomycin induced a delay of the cell-cycle traverse in G2 phase, the extent and recovery of which depended on drug concentration, exposure time, and cell cycle stage where treatment was applied. Different phase sensitivity for lethal damage (G2 phase) and kinetic response (early S phase) were documented. Recovery from G 2 block did not predict for unimpaired reproductive capacity.

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Pulse Cytophotometric Analysis of Cell Cycle Perturbation with Bleomycin in Vitro

Abstract

ASJC Scopus subject areas

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