TY - JOUR
T1 - Pupillary response
T2 - cognitive effort for breast cancer survivors
AU - Myers, Jamie S.
AU - Kahya, Melike
AU - Mitchell, Melissa
AU - Dai, Junqiang
AU - He, Jianghua
AU - Moon, Sanghee
AU - Hamilton, Kevin
AU - Valla, Mary
AU - O’Dea, Anne
AU - Klemp, Jennifer
AU - Kurylo, Monica
AU - Akinwuntan, Abiodun
AU - Devos, Hannes
N1 - Funding Information:
Funding information The study was funded by the University of Kansas Medical Center Frontiers Pilot & Collaborative Studies Award.
Publisher Copyright:
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Purpose: The purpose of this cross-sectional comparative pilot study was to evaluate cognitive effort, indexed by pupillary response (PR), for breast cancer survivors (BCS) with complaints of cognitive dysfunction following chemotherapy. Study Aims: Compare the cognitive effort employed by BCS to healthy controls (HC) during neuropsychological tests (NPT) for memory, sustained attention, verbal fluency, visuospatial ability, processing speed and executive function; and Investigate the relationship between PR-indexed cognitive effort and participants’ self-report of cognitive function. Methods: Self-report of cognitive function was collected from 23 BCS and 23 HC. PR was measured during NPT. Independent two-sample t tests or Wilcoxon rank sum tests were used to compare group scores. Between-group effect size (Cohen’s d) was calculated for each outcome. Correlation between mean self-report scores and PR values, as well as 95% confidence intervals, was calculated. Results: No group differences were demonstrated for NPT performance. BCS reported more issues with cognitive function than HC (p <.0001). A group effect for BCS was seen with PR-indexed cognitive effort for components of most NPT (p <.05). PR was correlated with most self-report measures of cognitive function (r = 0.33–0.45). Conclusions: PR sensitivity to cognitive effort across a variety of NPT and correlation with self-report of cognitive function was demonstrated. The portability, affordability, and “real-time” aspects of PR are attractive for potential use in the clinic setting to assess cognitive function. A larger study is needed to confirm these results. Prospective investigation of PR in BCS is needed to demonstrate sensitivity to cognitive function changes over time.
AB - Purpose: The purpose of this cross-sectional comparative pilot study was to evaluate cognitive effort, indexed by pupillary response (PR), for breast cancer survivors (BCS) with complaints of cognitive dysfunction following chemotherapy. Study Aims: Compare the cognitive effort employed by BCS to healthy controls (HC) during neuropsychological tests (NPT) for memory, sustained attention, verbal fluency, visuospatial ability, processing speed and executive function; and Investigate the relationship between PR-indexed cognitive effort and participants’ self-report of cognitive function. Methods: Self-report of cognitive function was collected from 23 BCS and 23 HC. PR was measured during NPT. Independent two-sample t tests or Wilcoxon rank sum tests were used to compare group scores. Between-group effect size (Cohen’s d) was calculated for each outcome. Correlation between mean self-report scores and PR values, as well as 95% confidence intervals, was calculated. Results: No group differences were demonstrated for NPT performance. BCS reported more issues with cognitive function than HC (p <.0001). A group effect for BCS was seen with PR-indexed cognitive effort for components of most NPT (p <.05). PR was correlated with most self-report measures of cognitive function (r = 0.33–0.45). Conclusions: PR sensitivity to cognitive effort across a variety of NPT and correlation with self-report of cognitive function was demonstrated. The portability, affordability, and “real-time” aspects of PR are attractive for potential use in the clinic setting to assess cognitive function. A larger study is needed to confirm these results. Prospective investigation of PR in BCS is needed to demonstrate sensitivity to cognitive function changes over time.
KW - Breast cancer
KW - Cognitive dysfunction
KW - Cognitive neuroscience
KW - Pupillary response
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U2 - 10.1007/s00520-018-4401-0
DO - 10.1007/s00520-018-4401-0
M3 - Article
C2 - 30097791
AN - SCOPUS:85051288341
SN - 0941-4355
VL - 27
SP - 1121
EP - 1128
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 3
ER -