TY - JOUR
T1 - Radiation and its impact on local recurrence in extremity and trunk well-differentiated liposarcomas
AU - Fonseca, Annabelle L.
AU - Roland, Christina L.
AU - Cormier, Janice N.
AU - Torres, Keila E.
AU - Hunt, Kelly H.
AU - Bishop, Andrew J.
AU - Guadagnolo, Ashleigh
AU - Feig, Barry W.
N1 - Publisher Copyright:
© 2019 Southeastern Surgical Congress. All Rights Reserved.
PY - 2019/1
Y1 - 2019/1
N2 - Patients with well-differentiated liposarcomas (WDLPS) of the extremity and trunk are treated primarily with surgical resection, with radiation used for a number of anecdotal reasons, including large size and positive margins. In this study, we evaluate the appropriate role for radiation in these tumors. A retrospective chart review of patients with extremity and trunk soft tissue liposarcomas referred to a free-standing cancer center from January 1995 to December 2011 was performed. One hundred eighty-three patients with extremity and trunk soft tissue WDLPS were identified: 61 per cent were female, median age was 60 years (range, 19–84 years) and 2 per cent had a focal area of dedifferentiation, margin status was positive in 57 per cent. Fourteen per cent of patients received radiation. Fifty patients developed recurrent disease; 28 per cent of these received radiation. Median time to recurrence was 18 years (range, 0.7–22 years). Of the 50 patients who recurred, 14 (28%) received radiation. Radiation was associated with decreased second recurrence when administered for recurrent disease (P 5 0.03). On multivariable analysis, tumor size £ 10 cm (P 5 0.014) and anatomically difficult area of resection (P 5 0.008) were predictive of increased risk of recurrence. Older age (P 5 0.02), dedifferentiated liposarcomas (P < 0.001), and difficult area of resection (P 5 0.02) were associated with the administration of radiotherapy. Administration of radiation therapy was not associated with decreased time to recurrence in WDLPS overall; however, it should be considered in patients with recurrent disease.
AB - Patients with well-differentiated liposarcomas (WDLPS) of the extremity and trunk are treated primarily with surgical resection, with radiation used for a number of anecdotal reasons, including large size and positive margins. In this study, we evaluate the appropriate role for radiation in these tumors. A retrospective chart review of patients with extremity and trunk soft tissue liposarcomas referred to a free-standing cancer center from January 1995 to December 2011 was performed. One hundred eighty-three patients with extremity and trunk soft tissue WDLPS were identified: 61 per cent were female, median age was 60 years (range, 19–84 years) and 2 per cent had a focal area of dedifferentiation, margin status was positive in 57 per cent. Fourteen per cent of patients received radiation. Fifty patients developed recurrent disease; 28 per cent of these received radiation. Median time to recurrence was 18 years (range, 0.7–22 years). Of the 50 patients who recurred, 14 (28%) received radiation. Radiation was associated with decreased second recurrence when administered for recurrent disease (P 5 0.03). On multivariable analysis, tumor size £ 10 cm (P 5 0.014) and anatomically difficult area of resection (P 5 0.008) were predictive of increased risk of recurrence. Older age (P 5 0.02), dedifferentiated liposarcomas (P < 0.001), and difficult area of resection (P 5 0.02) were associated with the administration of radiotherapy. Administration of radiation therapy was not associated with decreased time to recurrence in WDLPS overall; however, it should be considered in patients with recurrent disease.
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M3 - Article
C2 - 30760345
AN - SCOPUS:85061600963
SN - 0003-1348
VL - 85
SP - 52
EP - 58
JO - American Surgeon
JF - American Surgeon
IS - 1
ER -