Radiation Dose-Volume Effects of Optic Nerves and Chiasm

Charles Mayo; Mary K. Martel; Lawrence B. Marks; John Flickinger; Jiho Nam; John Kirkpatrick

doi:10.1016/j.ijrobp.2009.07.1753

Radiation Dose-Volume Effects of Optic Nerves and Chiasm

Charles Mayo, Mary K. Martel, Lawrence B. Marks, John Flickinger, Jiho Nam, John Kirkpatrick

Radiation Physics

Research output: Contribution to journal › Article › peer-review

406 Scopus citations

Abstract

Publications relating radiation toxicity of the optic nerves and chiasm to quantitative dose and dose-volume measures were reviewed. Few studies have adequate data for dose-volume outcome modeling. The risk of toxicity increased markedly at doses >60 Gy at ≈1.8 Gy/fraction and at >12 Gy for single-fraction radiosurgery. The evidence is strong that radiation tolerance is increased with a reduction in the dose per fraction. Models of threshold tolerance were examined.

Original language	English (US)
Pages (from-to)	S28-S35
Journal	International Journal of Radiation Oncology Biology Physics
Volume	76
Issue number	3 SUPPL.
DOIs	https://doi.org/10.1016/j.ijrobp.2009.07.1753
State	Published - Mar 1 2010

Keywords

Chiasm
Nerve
Optic
Radiotherapy
Tolerance

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/j.ijrobp.2009.07.1753

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abstract = "Publications relating radiation toxicity of the optic nerves and chiasm to quantitative dose and dose-volume measures were reviewed. Few studies have adequate data for dose-volume outcome modeling. The risk of toxicity increased markedly at doses >60 Gy at ≈1.8 Gy/fraction and at >12 Gy for single-fraction radiosurgery. The evidence is strong that radiation tolerance is increased with a reduction in the dose per fraction. Models of threshold tolerance were examined.",

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AU - Nam, Jiho

AU - Kirkpatrick, John

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KW - Chiasm

KW - Nerve

KW - Optic

KW - Radiotherapy

KW - Tolerance

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Radiation Dose-Volume Effects of Optic Nerves and Chiasm

Abstract

Keywords

ASJC Scopus subject areas

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