TY - JOUR
T1 - Radiation-Induced Cardiovascular Disease
T2 - A Clinical Perspective
AU - Yusuf, Syed Wamique
AU - Venkatesulu, Bhanu Prasad
AU - Mahadevan, Lakshmi Shree
AU - Krishnan, Sunil
N1 - Funding Information:
This work was partially supported by the MD Anderson Cancer Center support grant P30 CA16672 and the John E. and Dorothy J. Harris Endowed Professorship to SK.
Publisher Copyright:
© Copyright © 2017 Yusuf, Venkatesulu, Mahadevan and Krishnan.
PY - 2017/10/26
Y1 - 2017/10/26
N2 - Cancer survival has improved dramatically, and this has led to the manifestation of late side effects of multimodality therapy. Radiation (RT) to the thoracic malignancies results in unintentional irradiation of the cardiac chambers. RT-induced microvascular ischemia leads to disruption of capillary endothelial framework, and injury to differentiated myocytes results in deposition of collagen and fibrosis. Coexistence of risk factors of metabolic syndrome and preexisting atherosclerosis in addition to RT exposure results in accelerated occurrence of major coronary events. Hence, it becomes pertinent to understand the underlying pathophysiology and clinical manifestations of RT-induced cardiovascular disease to devise optimal preventive and surveillance strategies.
AB - Cancer survival has improved dramatically, and this has led to the manifestation of late side effects of multimodality therapy. Radiation (RT) to the thoracic malignancies results in unintentional irradiation of the cardiac chambers. RT-induced microvascular ischemia leads to disruption of capillary endothelial framework, and injury to differentiated myocytes results in deposition of collagen and fibrosis. Coexistence of risk factors of metabolic syndrome and preexisting atherosclerosis in addition to RT exposure results in accelerated occurrence of major coronary events. Hence, it becomes pertinent to understand the underlying pathophysiology and clinical manifestations of RT-induced cardiovascular disease to devise optimal preventive and surveillance strategies.
KW - biomarkers
KW - cancer
KW - cardiovascular disease
KW - ischemic heart disease
KW - radiation
UR - http://www.scopus.com/inward/record.url?scp=85048123155&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048123155&partnerID=8YFLogxK
U2 - 10.3389/fcvm.2017.00066
DO - 10.3389/fcvm.2017.00066
M3 - Review article
C2 - 29124057
AN - SCOPUS:85048123155
SN - 2297-055X
VL - 4
JO - Frontiers in Cardiovascular Medicine
JF - Frontiers in Cardiovascular Medicine
M1 - 66
ER -