TY - JOUR
T1 - Radiation protection against early and late effects of ionizing irradiation by the prostaglandin inhibitor indomethacin
AU - Milas, L.
AU - Nishiguchi, I.
AU - Hunter, N.
AU - Murray, D.
AU - Fleck, R.
AU - Ito, H.
AU - Travis, E.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1992
Y1 - 1992
N2 - Protective effects of indomethacin, a prototype prostaglandin-inhibiting agent, against early and late sequelae of radiation injury (after X-rays or γ-rays) in mice were investigated. The following tissues or organs were examined: hematopoietic tissue, esophagus, jejunum, colon, lung, hair follicles, and tissues involved in the development of radiation-induced leg contractures. In addition, the effect of indomethacin was tested against radiation-induced carcinogenesis. In all experiments, the radiation was delivered as a single dose. Indomethacin led to significant protection of hematopoietic tissue, by a factor of 1.3. There was also some protection against radiation-induced pneumonitis and against radiation-induced carcinogenesis (protection factor of 1.2). The other tissues tested showed no change in their radioresponse after being treated with indomethacin. Thus, indomethacin can act as a radioprotective agent against both early and late sequelae of radiation, but its effect is dependent on the tissue tested. This protection is smaller than that observed with WR-2721. However, indomethacin combined with WR-2721 produced a radioprotective effect greater than the radioprotection achieved by individual treatments.
AB - Protective effects of indomethacin, a prototype prostaglandin-inhibiting agent, against early and late sequelae of radiation injury (after X-rays or γ-rays) in mice were investigated. The following tissues or organs were examined: hematopoietic tissue, esophagus, jejunum, colon, lung, hair follicles, and tissues involved in the development of radiation-induced leg contractures. In addition, the effect of indomethacin was tested against radiation-induced carcinogenesis. In all experiments, the radiation was delivered as a single dose. Indomethacin led to significant protection of hematopoietic tissue, by a factor of 1.3. There was also some protection against radiation-induced pneumonitis and against radiation-induced carcinogenesis (protection factor of 1.2). The other tissues tested showed no change in their radioresponse after being treated with indomethacin. Thus, indomethacin can act as a radioprotective agent against both early and late sequelae of radiation, but its effect is dependent on the tissue tested. This protection is smaller than that observed with WR-2721. However, indomethacin combined with WR-2721 produced a radioprotective effect greater than the radioprotection achieved by individual treatments.
UR - http://www.scopus.com/inward/record.url?scp=0027105908&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027105908&partnerID=8YFLogxK
U2 - 10.1016/0273-1177(92)90116-F
DO - 10.1016/0273-1177(92)90116-F
M3 - Article
C2 - 11537017
AN - SCOPUS:0027105908
SN - 0273-1177
VL - 12
SP - 265
EP - 271
JO - Advances in Space Research
JF - Advances in Space Research
IS - 2-3
ER -