TY - JOUR
T1 - Radio-frequency ablation of liver tumors
T2 - Assessment of therapeutic response and complications
AU - Choi, Haesun
AU - Loyer, Evelyne M.
AU - DuBrow, Ronelle A.
AU - Kaur, Harmeet
AU - David, Cynthia L.
AU - Huang, Steven
AU - Curley, Steven
AU - Charnsangavej, Chusilp
PY - 2001
Y1 - 2001
N2 - An alternative to surgical resection of liver tumors, radio-frequency ablation induces in situ thermal coagulation necrosis through the delivery of high-frequency alternating current to the tissues. Imaging helps to detect treatable lesions, guide the placement of the probe, and assess the effect of therapy. Computed tomography (CT) is used most frequently to determine whether the ablation is complete and to screen for early recurrences that may benefit from reablation. Complete ablation creates an area of necrosis that, at CT, is of low attenuation compared with the surrounding liver tissue, is often homogeneous, and has smooth margins. The most important features are the size of the necrotic defect, which, immediately after treatment, should be larger than that of the pretreatment tumor, and the sharpness of the margins, which indicates an abrupt change in attenuation between the necrotic tissue and surrounding liver tissue. Enhancement, when present, is due to perfusion abnormality or granulation tissue and forms a regular rim or a homogeneous zone at the margin of the defect. It is seen immediately after ablation but may be prolonged. Enhancement is affected by the scanning technique. Over time, the size of the defect remains stable or decreases. Any variation from this general pattern is suggestive of incomplete ablation or recurrence.
AB - An alternative to surgical resection of liver tumors, radio-frequency ablation induces in situ thermal coagulation necrosis through the delivery of high-frequency alternating current to the tissues. Imaging helps to detect treatable lesions, guide the placement of the probe, and assess the effect of therapy. Computed tomography (CT) is used most frequently to determine whether the ablation is complete and to screen for early recurrences that may benefit from reablation. Complete ablation creates an area of necrosis that, at CT, is of low attenuation compared with the surrounding liver tissue, is often homogeneous, and has smooth margins. The most important features are the size of the necrotic defect, which, immediately after treatment, should be larger than that of the pretreatment tumor, and the sharpness of the margins, which indicates an abrupt change in attenuation between the necrotic tissue and surrounding liver tissue. Enhancement, when present, is due to perfusion abnormality or granulation tissue and forms a regular rim or a homogeneous zone at the margin of the defect. It is seen immediately after ablation but may be prolonged. Enhancement is affected by the scanning technique. Over time, the size of the defect remains stable or decreases. Any variation from this general pattern is suggestive of incomplete ablation or recurrence.
KW - Liver neoplasms, CT, 761.12114
KW - Liver neoplasms, MR, 761.12141
KW - Liver neoplasms, therapy, 761.30, 761.1269
KW - Radiofrequency (RF) ablation, 761.1269
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U2 - 10.1148/radiographics.21.suppl_1.g01oc08s41
DO - 10.1148/radiographics.21.suppl_1.g01oc08s41
M3 - Article
C2 - 11598247
AN - SCOPUS:6244288279
SN - 0271-5333
VL - 21
SP - S41-S54
JO - Radiographics
JF - Radiographics
IS - SPEC.ISS.
ER -