Radiotherapy and Late Effects

Joshua D. Palmer; Matthew D. Hall; Anita Mahajan; Arnold C. Paulino; Suzanne Wolden; Louis S. Constine

doi:10.1016/j.pcl.2020.08.001

Radiotherapy and Late Effects

Joshua D. Palmer, Matthew D. Hall, Anita Mahajan, Arnold C. Paulino, Suzanne Wolden, Louis S. Constine

Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Advances in multimodality care for patients with pediatric cancer continues to improve long-term survival. The use of surgery, chemotherapy, and radiotherapy may lead to debilitating late effects in childhood cancer survivors. It is critically important to understand, mitigate, and screen for late effects to improve the quality of life in childhood cancer survivors. This review summarizes the use of radiotherapy in children, radiobiology of tissue injury, impact of age on late effects, important organ systems affected by radiotherapy during survivorship, and screening for radiotherapy late effects.

Original language	English (US)
Pages (from-to)	1051-1067
Number of pages	17
Journal	Pediatric Clinics of North America
Volume	67
Issue number	6
DOIs	https://doi.org/10.1016/j.pcl.2020.08.001
State	Published - Dec 2020

Keywords

Late effects
Pediatric cancer
Radiobiology
Radiotherapy

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/j.pcl.2020.08.001

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title = "Radiotherapy and Late Effects",

abstract = "Advances in multimodality care for patients with pediatric cancer continues to improve long-term survival. The use of surgery, chemotherapy, and radiotherapy may lead to debilitating late effects in childhood cancer survivors. It is critically important to understand, mitigate, and screen for late effects to improve the quality of life in childhood cancer survivors. This review summarizes the use of radiotherapy in children, radiobiology of tissue injury, impact of age on late effects, important organ systems affected by radiotherapy during survivorship, and screening for radiotherapy late effects.",

keywords = "Late effects, Pediatric cancer, Radiobiology, Radiotherapy",

author = "Palmer, {Joshua D.} and Hall, {Matthew D.} and Anita Mahajan and Paulino, {Arnold C.} and Suzanne Wolden and Constine, {Louis S.}",

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T1 - Radiotherapy and Late Effects

AU - Palmer, Joshua D.

AU - Hall, Matthew D.

AU - Mahajan, Anita

AU - Paulino, Arnold C.

AU - Wolden, Suzanne

AU - Constine, Louis S.

PY - 2020/12

Y1 - 2020/12

N2 - Advances in multimodality care for patients with pediatric cancer continues to improve long-term survival. The use of surgery, chemotherapy, and radiotherapy may lead to debilitating late effects in childhood cancer survivors. It is critically important to understand, mitigate, and screen for late effects to improve the quality of life in childhood cancer survivors. This review summarizes the use of radiotherapy in children, radiobiology of tissue injury, impact of age on late effects, important organ systems affected by radiotherapy during survivorship, and screening for radiotherapy late effects.

AB - Advances in multimodality care for patients with pediatric cancer continues to improve long-term survival. The use of surgery, chemotherapy, and radiotherapy may lead to debilitating late effects in childhood cancer survivors. It is critically important to understand, mitigate, and screen for late effects to improve the quality of life in childhood cancer survivors. This review summarizes the use of radiotherapy in children, radiobiology of tissue injury, impact of age on late effects, important organ systems affected by radiotherapy during survivorship, and screening for radiotherapy late effects.

KW - Late effects

KW - Pediatric cancer

KW - Radiobiology

KW - Radiotherapy

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U2 - 10.1016/j.pcl.2020.08.001

DO - 10.1016/j.pcl.2020.08.001

M3 - Review article

C2 - 33131534

AN - SCOPUS:85094215887

SN - 0031-3955

VL - 67

SP - 1051

EP - 1067

JO - Pediatric Clinics of North America

JF - Pediatric Clinics of North America

IS - 6

ER -

Radiotherapy and Late Effects

Abstract

Keywords

ASJC Scopus subject areas

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