Radiotherapy outcome prediction with medical imaging

Kareem A. Wahid, Kendall J. Kiser, Keith L. Sanders, Christina Setareh Sharafi, Lance A. McCoy, Juan Ventura, Sara Ahmed, Clifton D. Fuller, Lisanne V. van Dijk

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter offers an in-depth exploration of advancements in imaging biomarker research within the realm of radiotherapy. It emphasizes radiomic models with high-dimensional feature sets tailored for supervised machine learning prediction. Specifically, this chapter reports on quantitative image biomarkers extracted from computed tomography, positron emission tomography, and magnetic resonance imaging modalities to formulate predictive models for clinical outcomes. Part 1 covers pre-treatment image biomarkers and their utility in predicting tumor response and normal tissue toxicity. Part 2 examines the change of image biomarkers during treatment, assessing their connection to dose and eventual outcomes. Part 3 addresses standardization, validation, interpretation, and practical applications of these biomarkers and models.

Original languageEnglish (US)
Title of host publicationMachine Learning and Artificial Intelligence in Radiation Oncology
Subtitle of host publicationA Guide for Clinicians
PublisherElsevier
Pages239-315
Number of pages77
ISBN (Electronic)9780128220009
DOIs
StatePublished - Jan 1 2023

Keywords

  • Medical imaging
  • Medical physics
  • Medical research
  • Neoplasia
  • Omics

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences
  • General Biochemistry, Genetics and Molecular Biology

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