Radiotherapy supports protective tumor-specific immunity

Anurag Gupta; Anu Sharma; Lotta von Boehmer; Laura Surace; Alexander Knuth; Maries van den Broek

doi:10.4161/onci.21478

Radiotherapy supports protective tumor-specific immunity

Anurag Gupta, Anu Sharma, Lotta von Boehmer, Laura Surace, Alexander Knuth, Maries van den Broek

Genitourinary Medical Oncology

Research output: Contribution to journal › Comment/debate › peer-review

26 Scopus citations

Abstract

Radiotherapy is an important therapeutic option for the treatment of cancer. Growing evidence indicates that, besides inducing an irreversible DNA damage, radiotherapy promotes tumor-specific immune response, which significantly contribute to therapeutic efficacy. We postulate that radiotherapy activates tumor-associated dendritic cells, thus changing the tolerogenic tumor environment into an immunogenic one.

Original language	English (US)
Pages (from-to)	1610-1611
Number of pages	2
Journal	OncoImmunology
Volume	1
Issue number	9
DOIs	https://doi.org/10.4161/onci.21478
State	Published - 2012

Keywords

CD8 T cells
Dendritic cells
Human
Mouse
Radiotherapy

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

Access to Document

10.4161/onci.21478

Cite this

@article{d4a60cbe59254e398a445d2bd94b65a4,

title = "Radiotherapy supports protective tumor-specific immunity",

abstract = "Radiotherapy is an important therapeutic option for the treatment of cancer. Growing evidence indicates that, besides inducing an irreversible DNA damage, radiotherapy promotes tumor-specific immune response, which significantly contribute to therapeutic efficacy. We postulate that radiotherapy activates tumor-associated dendritic cells, thus changing the tolerogenic tumor environment into an immunogenic one.",

keywords = "CD8 T cells, Dendritic cells, Human, Mouse, Radiotherapy",

author = "Anurag Gupta and Anu Sharma and {von Boehmer}, Lotta and Laura Surace and Alexander Knuth and {van den Broek}, Maries",

year = "2012",

doi = "10.4161/onci.21478",

language = "English (US)",

volume = "1",

pages = "1610--1611",

journal = "OncoImmunology",

issn = "2162-4011",

publisher = "Landes Bioscience",

number = "9",

}

TY - JOUR

T1 - Radiotherapy supports protective tumor-specific immunity

AU - Gupta, Anurag

AU - Sharma, Anu

AU - von Boehmer, Lotta

AU - Surace, Laura

AU - Knuth, Alexander

AU - van den Broek, Maries

PY - 2012

Y1 - 2012

N2 - Radiotherapy is an important therapeutic option for the treatment of cancer. Growing evidence indicates that, besides inducing an irreversible DNA damage, radiotherapy promotes tumor-specific immune response, which significantly contribute to therapeutic efficacy. We postulate that radiotherapy activates tumor-associated dendritic cells, thus changing the tolerogenic tumor environment into an immunogenic one.

AB - Radiotherapy is an important therapeutic option for the treatment of cancer. Growing evidence indicates that, besides inducing an irreversible DNA damage, radiotherapy promotes tumor-specific immune response, which significantly contribute to therapeutic efficacy. We postulate that radiotherapy activates tumor-associated dendritic cells, thus changing the tolerogenic tumor environment into an immunogenic one.

KW - CD8 T cells

KW - Dendritic cells

KW - Human

KW - Mouse

KW - Radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=84885389254&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885389254&partnerID=8YFLogxK

U2 - 10.4161/onci.21478

DO - 10.4161/onci.21478

M3 - Comment/debate

C2 - 23264910

AN - SCOPUS:84885389254

SN - 2162-4011

VL - 1

SP - 1610

EP - 1611

JO - OncoImmunology

JF - OncoImmunology

IS - 9

ER -

Radiotherapy supports protective tumor-specific immunity

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this