RAGs and regulation of autoantibodies

Mila Jankovic; Rafael Casellas; Nikos Yannoutsos; Hedda Wardemann; Michel C. Nussenzweig

doi:10.1146/annurev.immunol.22.012703.104707

RAGs and regulation of autoantibodies

Mila Jankovic, Rafael Casellas, Nikos Yannoutsos, Hedda Wardemann, Michel C. Nussenzweig

Research output: Contribution to journal › Review article › peer-review

73 Scopus citations

Abstract

Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow. Three mechanisms regulate autoreactive B cells: deletion, receptor editing, and anergy. Here we review the prevalence of autoantibodies in the initial antibody repertoire, their regulation by receptor editing, and the role of the recombinase proteins (RAG1 and RAG2) in this process.

Original language	English (US)
Pages (from-to)	485-501
Number of pages	17
Journal	Annual review of immunology
Volume	22
DOIs	https://doi.org/10.1146/annurev.immunol.22.012703.104707
State	Published - 2004
Externally published	Yes

Keywords

Antiself antibodies
B cell development
RAG1 and RAG2 expression
Receptor editing
Tolerance

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1146/annurev.immunol.22.012703.104707

Cite this

@article{aa5a2899453d4b35b47566f1291a54a6,

title = "RAGs and regulation of autoantibodies",

abstract = "Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow. Three mechanisms regulate autoreactive B cells: deletion, receptor editing, and anergy. Here we review the prevalence of autoantibodies in the initial antibody repertoire, their regulation by receptor editing, and the role of the recombinase proteins (RAG1 and RAG2) in this process.",

keywords = "Antiself antibodies, B cell development, RAG1 and RAG2 expression, Receptor editing, Tolerance",

author = "Mila Jankovic and Rafael Casellas and Nikos Yannoutsos and Hedda Wardemann and Nussenzweig, {Michel C.}",

year = "2004",

doi = "10.1146/annurev.immunol.22.012703.104707",

language = "English (US)",

volume = "22",

pages = "485--501",

journal = "Annual review of immunology",

issn = "0732-0582",

publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - RAGs and regulation of autoantibodies

AU - Jankovic, Mila

AU - Casellas, Rafael

AU - Yannoutsos, Nikos

AU - Wardemann, Hedda

AU - Nussenzweig, Michel C.

PY - 2004

Y1 - 2004

N2 - Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow. Three mechanisms regulate autoreactive B cells: deletion, receptor editing, and anergy. Here we review the prevalence of autoantibodies in the initial antibody repertoire, their regulation by receptor editing, and the role of the recombinase proteins (RAG1 and RAG2) in this process.

AB - Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow. Three mechanisms regulate autoreactive B cells: deletion, receptor editing, and anergy. Here we review the prevalence of autoantibodies in the initial antibody repertoire, their regulation by receptor editing, and the role of the recombinase proteins (RAG1 and RAG2) in this process.

KW - Antiself antibodies

KW - B cell development

KW - RAG1 and RAG2 expression

KW - Receptor editing

KW - Tolerance

UR - http://www.scopus.com/inward/record.url?scp=2542485540&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2542485540&partnerID=8YFLogxK

U2 - 10.1146/annurev.immunol.22.012703.104707

DO - 10.1146/annurev.immunol.22.012703.104707

M3 - Review article

C2 - 15032586

AN - SCOPUS:2542485540

SN - 0732-0582

VL - 22

SP - 485

EP - 501

JO - Annual review of immunology

JF - Annual review of immunology

ER -

RAGs and regulation of autoantibodies

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this