RAIDDing ER Stress for Oncolytic Viral Therapy

David J. McConkey

doi:10.1016/j.ccr.2011.10.002

RAIDDing ER Stress for Oncolytic Viral Therapy

David J. McConkey

Urology

Research output: Contribution to journal › Short survey › peer-review

3 Scopus citations

Abstract

Oncolytic viruses exploit molecular differences between normal and cancer cells to selectively kill the latter. Results of a synthetic lethal screen described in this issue of Cancer Cell demonstrate that components of the unfolded protein response (UPR) limit virus-induced tumor cell killing and identify a strategy to utilize this knowledge.

Original language	English (US)
Pages (from-to)	416-418
Number of pages	3
Journal	Cancer cell
Volume	20
Issue number	4
DOIs	https://doi.org/10.1016/j.ccr.2011.10.002
State	Published - Oct 18 2011

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

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10.1016/j.ccr.2011.10.002

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title = "RAIDDing ER Stress for Oncolytic Viral Therapy",

abstract = "Oncolytic viruses exploit molecular differences between normal and cancer cells to selectively kill the latter. Results of a synthetic lethal screen described in this issue of Cancer Cell demonstrate that components of the unfolded protein response (UPR) limit virus-induced tumor cell killing and identify a strategy to utilize this knowledge.",

author = "McConkey, {David J.}",

year = "2011",

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day = "18",

doi = "10.1016/j.ccr.2011.10.002",

language = "English (US)",

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pages = "416--418",

journal = "Cancer cell",

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AU - McConkey, David J.

PY - 2011/10/18

Y1 - 2011/10/18

N2 - Oncolytic viruses exploit molecular differences between normal and cancer cells to selectively kill the latter. Results of a synthetic lethal screen described in this issue of Cancer Cell demonstrate that components of the unfolded protein response (UPR) limit virus-induced tumor cell killing and identify a strategy to utilize this knowledge.

AB - Oncolytic viruses exploit molecular differences between normal and cancer cells to selectively kill the latter. Results of a synthetic lethal screen described in this issue of Cancer Cell demonstrate that components of the unfolded protein response (UPR) limit virus-induced tumor cell killing and identify a strategy to utilize this knowledge.

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U2 - 10.1016/j.ccr.2011.10.002

DO - 10.1016/j.ccr.2011.10.002

M3 - Short survey

C2 - 22014566

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SN - 1535-6108

VL - 20

SP - 416

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JO - Cancer cell

JF - Cancer cell

IS - 4

ER -

RAIDDing ER Stress for Oncolytic Viral Therapy

Abstract

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