Random plasma concentrations of voriconazole decline over time

Victor Mulanovich; Russell E. Lewis; Issam I. Raad; Dimitrios P. Kontoyiannis

doi:10.1016/j.jinf.2007.07.019

Random plasma concentrations of voriconazole decline over time

Victor Mulanovich, Russell E. Lewis, Issam I. Raad, Dimitrios P. Kontoyiannis

Infectious Diseases, Infection Control, and Employee Health

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

We retrospectively collected information about 29 cancer patients who underwent measurement of their plasma concentration (PC) of voriconazole (VRC) (2002-2006). Nine patients (31%) had VRC PC <1 μg/ml. VRC PC <1 μg/ml occurred in 7 of 10 patients who were on VRC >2 months versus only 2 of 19 patients who were on VRC <2 months (P = 0.001). VRC PCs were infrequently ordered, did not follow clear indications, and the use of the results was variable.

Original language	English (US)
Pages (from-to)	e129-e130
Journal	Journal of Infection
Volume	55
Issue number	5
DOIs	https://doi.org/10.1016/j.jinf.2007.07.019
State	Published - Nov 2007

Keywords

Cancer
Fungal infections
Voriconazole

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/j.jinf.2007.07.019

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title = "Random plasma concentrations of voriconazole decline over time",

abstract = "We retrospectively collected information about 29 cancer patients who underwent measurement of their plasma concentration (PC) of voriconazole (VRC) (2002-2006). Nine patients (31%) had VRC PC <1 μg/ml. VRC PC <1 μg/ml occurred in 7 of 10 patients who were on VRC >2 months versus only 2 of 19 patients who were on VRC <2 months (P = 0.001). VRC PCs were infrequently ordered, did not follow clear indications, and the use of the results was variable.",

keywords = "Cancer, Fungal infections, Voriconazole",

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AU - Mulanovich, Victor

AU - Lewis, Russell E.

AU - Raad, Issam I.

AU - Kontoyiannis, Dimitrios P.

PY - 2007/11

Y1 - 2007/11

N2 - We retrospectively collected information about 29 cancer patients who underwent measurement of their plasma concentration (PC) of voriconazole (VRC) (2002-2006). Nine patients (31%) had VRC PC <1 μg/ml. VRC PC <1 μg/ml occurred in 7 of 10 patients who were on VRC >2 months versus only 2 of 19 patients who were on VRC <2 months (P = 0.001). VRC PCs were infrequently ordered, did not follow clear indications, and the use of the results was variable.

AB - We retrospectively collected information about 29 cancer patients who underwent measurement of their plasma concentration (PC) of voriconazole (VRC) (2002-2006). Nine patients (31%) had VRC PC <1 μg/ml. VRC PC <1 μg/ml occurred in 7 of 10 patients who were on VRC >2 months versus only 2 of 19 patients who were on VRC <2 months (P = 0.001). VRC PCs were infrequently ordered, did not follow clear indications, and the use of the results was variable.

KW - Cancer

KW - Fungal infections

KW - Voriconazole

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IS - 5

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Random plasma concentrations of voriconazole decline over time

Abstract

Keywords

ASJC Scopus subject areas

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