TY - JOUR
T1 - Rapid head and neck tissue identification in thyroid and parathyroid surgery using optical coherence tomography
AU - Yang, Nathan
AU - Boudoux, Caroline
AU - De Montigny, Etienne
AU - Maniakas, Anastasios
AU - Gologan, Olga
AU - Madore, Wendy Julie
AU - Khullar, Sharmila
AU - Guertin, Louis
AU - Christopoulos, Apostolos
AU - Bissada, Eric
AU - Ayad, Tareck
N1 - Funding Information:
The generous support of the Natural Sciences and Engineering Research Council of Canada (NSERC), and the Canadian Institutes of Health Research (CIHR).
Publisher Copyright:
© 2019 Wiley Periodicals, Inc.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Background: Optical coherence tomography (OCT) is a noninvasive imaging modality that may reproduce the microarchitecture of tissues in real-time. This study examines whether OCT can render distinct images of thyroid, parathyroid glands, adipose tissue, and lymph nodes in both healthy and pathological states. Methods: Twenty-seven patients undergoing thyroidectomy, parathyroidectomy, and/or neck dissection for thyroid cancer were recruited prospectively for imaging prior to histopathological analysis. Results: Based on 122 imaged specimens, qualitative OCT descriptions were derived for healthy thyroid, parathyroid gland, adipose tissue, and lymph node. The frequencies at which distinguishing features were present for each tissue type were 88%, 83%, 100%, and 82%. OCT appearance of pathological specimens were also described. Conclusions: Healthy neck tissues have distinct OCT appearances, which could facilitate parathyroid identification during thyroidectomies. However, images of parathyroid adenomas could be confused with those of lymph nodes, and benign and malignant thyroid nodules could not be differentiated.
AB - Background: Optical coherence tomography (OCT) is a noninvasive imaging modality that may reproduce the microarchitecture of tissues in real-time. This study examines whether OCT can render distinct images of thyroid, parathyroid glands, adipose tissue, and lymph nodes in both healthy and pathological states. Methods: Twenty-seven patients undergoing thyroidectomy, parathyroidectomy, and/or neck dissection for thyroid cancer were recruited prospectively for imaging prior to histopathological analysis. Results: Based on 122 imaged specimens, qualitative OCT descriptions were derived for healthy thyroid, parathyroid gland, adipose tissue, and lymph node. The frequencies at which distinguishing features were present for each tissue type were 88%, 83%, 100%, and 82%. OCT appearance of pathological specimens were also described. Conclusions: Healthy neck tissues have distinct OCT appearances, which could facilitate parathyroid identification during thyroidectomies. However, images of parathyroid adenomas could be confused with those of lymph nodes, and benign and malignant thyroid nodules could not be differentiated.
KW - imaging
KW - optical coherence tomography
KW - parathyroid
KW - thyroid
KW - tissue biopsy
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U2 - 10.1002/hed.25972
DO - 10.1002/hed.25972
M3 - Article
C2 - 31571306
AN - SCOPUS:85073992494
SN - 1043-3074
VL - 41
SP - 4171
EP - 4180
JO - Head and Neck
JF - Head and Neck
IS - 12
ER -