TY - JOUR
T1 - Rapidly progressing cervical cancer in a patient with human immunodeficiency virus infection
AU - Rellihan, Marcia A.
AU - Dooley, David P.
AU - Burke, Thomas W.
AU - Berkland, Michael E.
AU - Longfield, Robert N.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1990/3
Y1 - 1990/3
N2 - Many malignancies occur in association with the acquired immunodeficiency syndrome (AIDS). The incidence of cervical intraepithelial neoplasia is increased in patients with human immunodeficiency virus (HIV) infection, although coexistent HIV infection and cervical cancer have not been described. We describe a patient with HIV infection and a stage IIB, poorly differentiated cervical carcinoma who initially responded well to standard radiation therapy. Relapse at an unusual periclitoral site as well as disseminated carcinomatosis appeared within 2 months. Despite chemotherapy with cisplatin, bleomycin, and mitomycin C, the patient died within 3 months of relapse. This pattern of aggressive tumor behavior may occur more frequently as HIV infection spreads into the heterosexual population. We recommend frequent pelvic and cytologic examinations of HIV-infected women and the consideration of an aggressive treatment approach should invasive carcinoma be detected.
AB - Many malignancies occur in association with the acquired immunodeficiency syndrome (AIDS). The incidence of cervical intraepithelial neoplasia is increased in patients with human immunodeficiency virus (HIV) infection, although coexistent HIV infection and cervical cancer have not been described. We describe a patient with HIV infection and a stage IIB, poorly differentiated cervical carcinoma who initially responded well to standard radiation therapy. Relapse at an unusual periclitoral site as well as disseminated carcinomatosis appeared within 2 months. Despite chemotherapy with cisplatin, bleomycin, and mitomycin C, the patient died within 3 months of relapse. This pattern of aggressive tumor behavior may occur more frequently as HIV infection spreads into the heterosexual population. We recommend frequent pelvic and cytologic examinations of HIV-infected women and the consideration of an aggressive treatment approach should invasive carcinoma be detected.
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U2 - 10.1016/0090-8258(90)90159-I
DO - 10.1016/0090-8258(90)90159-I
M3 - Article
C2 - 2318457
AN - SCOPUS:0025262106
SN - 0090-8258
VL - 36
SP - 435
EP - 438
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 3
ER -