TY - JOUR
T1 - Rare manifestations of Churg-Strauss syndrome with mediastinal and Hilar Lymphadenopathies
T2 - Report of an autopsy case
AU - Cho, Woo Cheal
AU - Ramlal, Bharat
AU - Fiel-Gan, Mary
AU - Song, Xianyuan
N1 - Publisher Copyright:
© 2019 The Korean Society of Pathologists/The Korean Society for Cytopathology.
PY - 2019
Y1 - 2019
N2 - Churg-Strauss syndrome (CSS) is a rare systemic disorder that is classically characterized by asthma, tissue and blood eosinophilia, and necrotizing vasculitis along with a granulomatous response to eosinophilic necrosis in its full-blown form. It has a predilection for small- and medium-sized vessels of the lungs, but can virtually affect any organ system, including the heart, skin, gastrointestinal tract, and nervous system. Involvement of the lymph node in CSS, however, is still rare with only a few cases reported in the English literature.1-6 Furthermore, the classic histologic features of CSS, particularly necrotizing vasculitis, are infrequently captured in the modern biopsy or autopsy specimens due to the widespread use of steroids.7 Here, we report the autopsy findings of a 69-year-old man with CSS involving mediastinal and hilar lymph nodes and discuss the histologic features of partially treated CSS. Formal written informed consent was not required with a waiver by the appropriate institutional review board and/or national research ethics committee (FWA00021932).
AB - Churg-Strauss syndrome (CSS) is a rare systemic disorder that is classically characterized by asthma, tissue and blood eosinophilia, and necrotizing vasculitis along with a granulomatous response to eosinophilic necrosis in its full-blown form. It has a predilection for small- and medium-sized vessels of the lungs, but can virtually affect any organ system, including the heart, skin, gastrointestinal tract, and nervous system. Involvement of the lymph node in CSS, however, is still rare with only a few cases reported in the English literature.1-6 Furthermore, the classic histologic features of CSS, particularly necrotizing vasculitis, are infrequently captured in the modern biopsy or autopsy specimens due to the widespread use of steroids.7 Here, we report the autopsy findings of a 69-year-old man with CSS involving mediastinal and hilar lymph nodes and discuss the histologic features of partially treated CSS. Formal written informed consent was not required with a waiver by the appropriate institutional review board and/or national research ethics committee (FWA00021932).
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U2 - 10.4132/jptm.2017.12.13
DO - 10.4132/jptm.2017.12.13
M3 - Article
C2 - 29249116
AN - SCOPUS:85065473449
SN - 2383-7837
VL - 53
SP - 66
EP - 69
JO - Journal of Pathology and Translational Medicine
JF - Journal of Pathology and Translational Medicine
IS - 1
ER -