TY - JOUR
T1 - Re-treatment of patients with recurrent epithelial ovarian cancer with cisplatin-based chemotherapy
AU - Gershenson, David M.
AU - Kavanagh, John J.
AU - Copeland, Larry J.
AU - Stringer, C. Allen
AU - Morris, Mitchell
AU - Wharton, J. Taylor
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1989/5
Y1 - 1989/5
N2 - Nineteen patients with recurrent epithelial ovarian cancer who had responded to initial cisplatin-based combination chemotherapy were re-treated with cisplatin-based therapy. The median disease-free interval, as measured from the last cycle of primary chemotherapy to the diagnosis of relapse, was 26.3 months (range 5–81 months). Eighteen of the 19 patients had measurable disease at the time of relapse. Nine patients had a clinical complete response to the cisplatin-based re-treatment, and nine patients had a partial response (surgically documented in one case). The overall response rate to secondary cisplatin-based chemotherapy was therefore 100% in patients with measurable disease. Toxicity of re-treatment was acceptable. The median progression-free survival, as measured from the diagnosis of relapse to the time of disease progression, was 10.6 months (range 4–24 months). The median survival from diagnosis of relapse was 19.3 months (range 5–39 months). At the time of analysis, three patients were alive without evidence of disease, four were alive with tumor, and 12 were dead of cancer. These data suggest that re-induction with cisplatin-based chemotherapy should be considered for patients who develop recurrent disease after favorable responses to primary cisplatin-based chemotherapy.
AB - Nineteen patients with recurrent epithelial ovarian cancer who had responded to initial cisplatin-based combination chemotherapy were re-treated with cisplatin-based therapy. The median disease-free interval, as measured from the last cycle of primary chemotherapy to the diagnosis of relapse, was 26.3 months (range 5–81 months). Eighteen of the 19 patients had measurable disease at the time of relapse. Nine patients had a clinical complete response to the cisplatin-based re-treatment, and nine patients had a partial response (surgically documented in one case). The overall response rate to secondary cisplatin-based chemotherapy was therefore 100% in patients with measurable disease. Toxicity of re-treatment was acceptable. The median progression-free survival, as measured from the diagnosis of relapse to the time of disease progression, was 10.6 months (range 4–24 months). The median survival from diagnosis of relapse was 19.3 months (range 5–39 months). At the time of analysis, three patients were alive without evidence of disease, four were alive with tumor, and 12 were dead of cancer. These data suggest that re-induction with cisplatin-based chemotherapy should be considered for patients who develop recurrent disease after favorable responses to primary cisplatin-based chemotherapy.
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M3 - Article
C2 - 2704508
AN - SCOPUS:0024589974
SN - 0029-7844
VL - 73
SP - 798
EP - 802
JO - Obstetrics and gynecology
JF - Obstetrics and gynecology
IS - 5
ER -