Real-time spectroscopic evaluation of oral lesions and comparisons with histopathology

Richard A. Schwarz; Wen Gao; Jennifer Nguyen; Nadarajah Vigneswaran; Karen Adler-Storthz; Vijayashree S. Bhattar; Michelle D. Williams; Ann M. Gillenwater; Rebecca Richards-Kortum

doi:10.1117/12.887758

Real-time spectroscopic evaluation of oral lesions and comparisons with histopathology

Richard A. Schwarz, Wen Gao, Jennifer Nguyen, Nadarajah Vigneswaran, Karen Adler-Storthz, Vijayashree S. Bhattar, Michelle D. Williams, Ann M. Gillenwater, Rebecca Richards-Kortum

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Optical techniques including widefield autofluorescence and reflectance imaging, depth-sensitive optical spectroscopy, and high-resolution imaging can be used to noninvasively detect dysplastic and cancerous alterations in oral tissue. The diagnostic performance of depth-sensitive optical spectroscopy with respect to histopathology is examined. A compact, portable spectroscopy device for clinical use is described. Practical considerations for the comparison of optical measurements to histopathologic diagnoses are outlined. Important considerations for comparison to histopathology include the physical correspondence of the measured region to the biopsy or specimen; data collection and processing procedures; and data analysis procedures. Multimodal combinations of widefield imaging, point spectroscopy, and highresolution imaging may enhance the ability of clinicians to accurately assess the margins of neoplastic oral lesions in vivo.

Original language	English (US)
Title of host publication	Photonic Therapeutics and Diagnostics VII
DOIs	https://doi.org/10.1117/12.887758
State	Published - 2011
Event	Photonic Therapeutics and Diagnostics VII - San Francisco, CA, United States Duration: Jan 22 2011 → Jan 24 2011

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	7883
ISSN (Print)	1605-7422

Other

Other	Photonic Therapeutics and Diagnostics VII
Country/Territory	United States
City	San Francisco, CA
Period	1/22/11 → 1/24/11

Keywords

imaging
oral cancer
spectroscopy
tissue diagnostics

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.887758

Cite this

Schwarz, R. A., Gao, W., Nguyen, J., Vigneswaran, N., Adler-Storthz, K., Bhattar, V. S., Williams, M. D., Gillenwater, A. M., & Richards-Kortum, R. (2011). Real-time spectroscopic evaluation of oral lesions and comparisons with histopathology. In Photonic Therapeutics and Diagnostics VII Article 78832K (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7883). https://doi.org/10.1117/12.887758

Schwarz, RA, Gao, W, Nguyen, J, Vigneswaran, N, Adler-Storthz, K, Bhattar, VS, Williams, MD , Gillenwater, AM & Richards-Kortum, R 2011, Real-time spectroscopic evaluation of oral lesions and comparisons with histopathology. in Photonic Therapeutics and Diagnostics VII., 78832K, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 7883, Photonic Therapeutics and Diagnostics VII, San Francisco, CA, United States, 1/22/11. https://doi.org/10.1117/12.887758

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title = "Real-time spectroscopic evaluation of oral lesions and comparisons with histopathology",

abstract = "Optical techniques including widefield autofluorescence and reflectance imaging, depth-sensitive optical spectroscopy, and high-resolution imaging can be used to noninvasively detect dysplastic and cancerous alterations in oral tissue. The diagnostic performance of depth-sensitive optical spectroscopy with respect to histopathology is examined. A compact, portable spectroscopy device for clinical use is described. Practical considerations for the comparison of optical measurements to histopathologic diagnoses are outlined. Important considerations for comparison to histopathology include the physical correspondence of the measured region to the biopsy or specimen; data collection and processing procedures; and data analysis procedures. Multimodal combinations of widefield imaging, point spectroscopy, and highresolution imaging may enhance the ability of clinicians to accurately assess the margins of neoplastic oral lesions in vivo.",

keywords = "imaging, oral cancer, spectroscopy, tissue diagnostics",

author = "Schwarz, {Richard A.} and Wen Gao and Jennifer Nguyen and Nadarajah Vigneswaran and Karen Adler-Storthz and Bhattar, {Vijayashree S.} and Williams, {Michelle D.} and Gillenwater, {Ann M.} and Rebecca Richards-Kortum",

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AU - Schwarz, Richard A.

AU - Gao, Wen

AU - Nguyen, Jennifer

AU - Vigneswaran, Nadarajah

AU - Adler-Storthz, Karen

AU - Bhattar, Vijayashree S.

AU - Williams, Michelle D.

AU - Gillenwater, Ann M.

AU - Richards-Kortum, Rebecca

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AB - Optical techniques including widefield autofluorescence and reflectance imaging, depth-sensitive optical spectroscopy, and high-resolution imaging can be used to noninvasively detect dysplastic and cancerous alterations in oral tissue. The diagnostic performance of depth-sensitive optical spectroscopy with respect to histopathology is examined. A compact, portable spectroscopy device for clinical use is described. Practical considerations for the comparison of optical measurements to histopathologic diagnoses are outlined. Important considerations for comparison to histopathology include the physical correspondence of the measured region to the biopsy or specimen; data collection and processing procedures; and data analysis procedures. Multimodal combinations of widefield imaging, point spectroscopy, and highresolution imaging may enhance the ability of clinicians to accurately assess the margins of neoplastic oral lesions in vivo.

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KW - oral cancer

KW - spectroscopy

KW - tissue diagnostics

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Y2 - 22 January 2011 through 24 January 2011

ER -

Real-time spectroscopic evaluation of oral lesions and comparisons with histopathology

Abstract

Publication series

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Keywords

ASJC Scopus subject areas

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