TY - JOUR
T1 - Receiving information on fertility- and menopause-related treatment effects among women who undergo hematopoietic stem cell transplantation
T2 - Changes in perceived importance over time
AU - Nakayama, Kazutaka
AU - Liu, Ping
AU - Detry, Michelle
AU - Schover, Leslie R.
AU - Milbourne, Andrea
AU - Neumann, Joyce
AU - Rondon, Gabriela
AU - Thewes, Belinda
AU - Champlin, Richard E.
AU - Ueno, Naoto T.
PY - 2009/11
Y1 - 2009/11
N2 - Hematopoietic stem-cell transplantation (HSCT) is associated with high rates of gonadal failure, which is distressing for younger patients desiring to start a family. The perceived importance and optimal timing of discussing fertility- and menopause-related information with women undergoing aggressive treatment such as HSCT is not well defined. Questionnaires were sent to 532 patients who underwent HSCT between January 1987 and September 2004 at the ages of 16 to 50 years. The questionnaire assessed demographic data, the need for fertility- and menopause-related information at various times during treatment, and standardized measures of anxiety, quality of life, and menopausal symptoms. The return rate was 40.2%, with 196 patients participating. Of these, 38% reported that they had discussed fertility-related issues with health-care providers since their diagnosis; 54% had discussed menopause-related issues. At the time of diagnosis, participants considered receiving information on fertility and menopause as being of equal importance. However, after HSCT, information about menopause was considered more important than information on fertility (P ≤.0001). Being <40 years, being childless, desiring to bear children in the future, and having a high score on the State-Trait Anxiety Inventory (STAI) correlated with higher ratings of importance for both fertility- and menopause-related information. Our results suggested that healthcare providers should provide information on fertility and menopause repeatedly throughout the treatment period, and that menopause-related information should be reemphasized after HSCT. Such counseling is crucial for patients who are young and childless.
AB - Hematopoietic stem-cell transplantation (HSCT) is associated with high rates of gonadal failure, which is distressing for younger patients desiring to start a family. The perceived importance and optimal timing of discussing fertility- and menopause-related information with women undergoing aggressive treatment such as HSCT is not well defined. Questionnaires were sent to 532 patients who underwent HSCT between January 1987 and September 2004 at the ages of 16 to 50 years. The questionnaire assessed demographic data, the need for fertility- and menopause-related information at various times during treatment, and standardized measures of anxiety, quality of life, and menopausal symptoms. The return rate was 40.2%, with 196 patients participating. Of these, 38% reported that they had discussed fertility-related issues with health-care providers since their diagnosis; 54% had discussed menopause-related issues. At the time of diagnosis, participants considered receiving information on fertility and menopause as being of equal importance. However, after HSCT, information about menopause was considered more important than information on fertility (P ≤.0001). Being <40 years, being childless, desiring to bear children in the future, and having a high score on the State-Trait Anxiety Inventory (STAI) correlated with higher ratings of importance for both fertility- and menopause-related information. Our results suggested that healthcare providers should provide information on fertility and menopause repeatedly throughout the treatment period, and that menopause-related information should be reemphasized after HSCT. Such counseling is crucial for patients who are young and childless.
KW - Hematopoeitic stem cell transplantation
KW - Infertility
KW - Information provision
KW - Premature ovarian failure
KW - Questionnarie survey
UR - http://www.scopus.com/inward/record.url?scp=70350614908&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350614908&partnerID=8YFLogxK
U2 - 10.1016/j.bbmt.2009.07.019
DO - 10.1016/j.bbmt.2009.07.019
M3 - Article
C2 - 19822307
AN - SCOPUS:70350614908
SN - 1083-8791
VL - 15
SP - 1465
EP - 1474
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 11
ER -