TY - JOUR
T1 - Recent advances in nanomedicine for the diagnosis and treatment of prostate cancer bone metastasis
AU - Hagaman, Daniel E.
AU - Damasco, Jossana A.
AU - Perez, Joy Vanessa D.
AU - Rojo, Raniv D.
AU - Melancon, Marites P.
N1 - Funding Information:
Funding: The publication cost was funded by MD Anderson Institutional Grant (to M.P.M).
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/1/2
Y1 - 2021/1/2
N2 - Patients with advanced prostate cancer can develop painful and debilitating bone metastases. Currently available interventions for prostate cancer bone metastases, including chemotherapy, bisphosphonates, and radiopharmaceuticals, are only palliative. They can relieve pain, reduce complications (e.g., bone fractures), and improve quality of life, but they do not significantly improve survival times. Therefore, additional strategies to enhance the diagnosis and treatment of prostate cancer bone metastases are needed. Nanotechnology is a versatile platform that has been used to increase the specificity and therapeutic efficacy of various treatments for prostate cancer bone metastases. In this review, we summarize preclinical research that utilizes nanotechnology to develop novel diagnostic imaging tools, translational models, and therapies to combat prostate cancer bone metastases.
AB - Patients with advanced prostate cancer can develop painful and debilitating bone metastases. Currently available interventions for prostate cancer bone metastases, including chemotherapy, bisphosphonates, and radiopharmaceuticals, are only palliative. They can relieve pain, reduce complications (e.g., bone fractures), and improve quality of life, but they do not significantly improve survival times. Therefore, additional strategies to enhance the diagnosis and treatment of prostate cancer bone metastases are needed. Nanotechnology is a versatile platform that has been used to increase the specificity and therapeutic efficacy of various treatments for prostate cancer bone metastases. In this review, we summarize preclinical research that utilizes nanotechnology to develop novel diagnostic imaging tools, translational models, and therapies to combat prostate cancer bone metastases.
KW - Bone metastasis
KW - Nanomedicine
KW - Nanotechnology
KW - Prostate cancer
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U2 - 10.3390/molecules26020384
DO - 10.3390/molecules26020384
M3 - Review article
C2 - 33450939
AN - SCOPUS:85100120999
SN - 1420-3049
VL - 26
JO - Molecules
JF - Molecules
IS - 2
M1 - 384
ER -