TY - JOUR
T1 - Recent insights into the nutritional immunomodulation of cancer-related microRNAs
AU - Şahin, Teslime Özge
AU - Yılmaz, Birsen
AU - Yeşilyurt, Neslihan
AU - Cicia, Donatella
AU - Szymanowska, Anna
AU - Amero, Paola
AU - Ağagündüz, Duygu
AU - Capasso, Raffaele
N1 - Publisher Copyright:
© 2023 The Authors. Phytotherapy Research published by John Wiley & Sons Ltd.
PY - 2023/10
Y1 - 2023/10
N2 - Cancer is the most common cause of death worldwide, following cardiovascular diseases. Cancer is a multifactorial disease and many reasons such as physical, chemical, biological, and lifestyle-related factors. Nutrition, which is one of the various factors that play a role in the prevention, development, and treatment of many types of cancer, affects the immune system, which is characterized by disproportionate pro-inflammatory signaling in cancer. Studies investigating the molecular mechanisms of this effect have shown that foods rich in bioactive compounds, such as green tea, olive oil, turmeric, and soybean play a significant role in positively changing the expression of miRNAs involved in the regulation of genes associated with oncogenic/tumor-suppressing pathways. In addition to these foods, some diet models may change the expression of specific cancer-related miRNAs in different ways. While Mediterranean diet has been associated with anticancer effects, a high-fat diet, and a methyl-restricted diet are considered to have negative effects. This review aims to discuss the effects of specific foods called “immune foods,” diet models, and bioactive components on cancer by changing the expression of miRNAs in the prevention and treatment of cancer.
AB - Cancer is the most common cause of death worldwide, following cardiovascular diseases. Cancer is a multifactorial disease and many reasons such as physical, chemical, biological, and lifestyle-related factors. Nutrition, which is one of the various factors that play a role in the prevention, development, and treatment of many types of cancer, affects the immune system, which is characterized by disproportionate pro-inflammatory signaling in cancer. Studies investigating the molecular mechanisms of this effect have shown that foods rich in bioactive compounds, such as green tea, olive oil, turmeric, and soybean play a significant role in positively changing the expression of miRNAs involved in the regulation of genes associated with oncogenic/tumor-suppressing pathways. In addition to these foods, some diet models may change the expression of specific cancer-related miRNAs in different ways. While Mediterranean diet has been associated with anticancer effects, a high-fat diet, and a methyl-restricted diet are considered to have negative effects. This review aims to discuss the effects of specific foods called “immune foods,” diet models, and bioactive components on cancer by changing the expression of miRNAs in the prevention and treatment of cancer.
KW - bioactive components
KW - cancer prevention
KW - flavonoids
KW - miRNA
KW - postbiotics
KW - probiotics
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U2 - 10.1002/ptr.7937
DO - 10.1002/ptr.7937
M3 - Review article
C2 - 37434291
AN - SCOPUS:85164813611
SN - 0951-418X
VL - 37
SP - 4375
EP - 4397
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 10
ER -