Receptor protein tyrosine kinase DDR is up-regulated by p53 protein

Shirou Sakuma; Hideyuki Saya; Mitsuhiro Tada; Mitsuyoshi Nakao; Toshiyoshi Fujiwara; Jack A. Roth; Yutaka Sawamura; Yumiko Shinohe; Abe Hiroshi

doi:10.1016/S0014-5793(96)01234-3

Receptor protein tyrosine kinase DDR is up-regulated by p53 protein

Shirou Sakuma, Hideyuki Saya, Mitsuhiro Tada, Mitsuyoshi Nakao, Toshiyoshi Fujiwara, Jack A. Roth, Yutaka Sawamura, Yumiko Shinohe, Abe Hiroshi

Thoracic & Cardiovascular Surgery

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30 Scopus citations

Abstract

We have previously reported on radiation-induction of ptk-3 in rat astr ocyte culture [Sakuma et al. (1995) Radiat. Res. 143, 1-7]. Ptk-3 was considered to be a rat version of human DDR (discoidin domain receptor). We cloned and analyzed genomic DNA of the DDR and its promoter region. We discovered that the promoter region contained a consensus sequence of the p53 tumor suppressor binding site. Adenovirus-mediated p53 transfection induced a high level of DDR mRNA in SAOS2 human osteosarcoma cells. These results indicate that DDR is up-regulated by the p53 protein.

Original language	English (US)
Pages (from-to)	165-169
Number of pages	5
Journal	FEBS Letters
Volume	398
Issue number	2-3
DOIs	https://doi.org/10.1016/S0014-5793(96)01234-3
State	Published - Dec 2 1996

Keywords

Genomic DNA structure
Human DDR gene
p53 regulatory element

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/S0014-5793(96)01234-3

Cite this

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abstract = "We have previously reported on radiation-induction of ptk-3 in rat astr ocyte culture [Sakuma et al. (1995) Radiat. Res. 143, 1-7]. Ptk-3 was considered to be a rat version of human DDR (discoidin domain receptor). We cloned and analyzed genomic DNA of the DDR and its promoter region. We discovered that the promoter region contained a consensus sequence of the p53 tumor suppressor binding site. Adenovirus-mediated p53 transfection induced a high level of DDR mRNA in SAOS2 human osteosarcoma cells. These results indicate that DDR is up-regulated by the p53 protein.",

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AU - Sakuma, Shirou

AU - Saya, Hideyuki

AU - Tada, Mitsuhiro

AU - Nakao, Mitsuyoshi

AU - Fujiwara, Toshiyoshi

AU - Roth, Jack A.

AU - Sawamura, Yutaka

AU - Shinohe, Yumiko

AU - Hiroshi, Abe

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AB - We have previously reported on radiation-induction of ptk-3 in rat astr ocyte culture [Sakuma et al. (1995) Radiat. Res. 143, 1-7]. Ptk-3 was considered to be a rat version of human DDR (discoidin domain receptor). We cloned and analyzed genomic DNA of the DDR and its promoter region. We discovered that the promoter region contained a consensus sequence of the p53 tumor suppressor binding site. Adenovirus-mediated p53 transfection induced a high level of DDR mRNA in SAOS2 human osteosarcoma cells. These results indicate that DDR is up-regulated by the p53 protein.

KW - Genomic DNA structure

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KW - p53 regulatory element

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Receptor protein tyrosine kinase DDR is up-regulated by p53 protein

Abstract

Keywords

ASJC Scopus subject areas

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