@inbook{3461d4085c7048df9765bc8e93ee4eb4,
title = "Receptor tyrosine kinases in the nucleus: Nuclear functions and therapeutic implications in cancers",
abstract = "Receptor tyrosine kinases (RTKs), originally considered as cell surface receptors responsible for transmitting external signals into the interior of cells through diverse signaling cascades, have now been demonstrated to also localize within cells to different compartments such as the nucleus and the mitochondria in addition to their cell surface localization. They also exhibit biological functions when located at the particular cellular compartments. There is increasing evidence indicating that nuclear RTKs, like their cell surface counterparts, are also involved directly in regulating gene expression and DNA repair and replication, leading to cell proliferation, survival, and insensitivity to therapeutic agents. Here, we discuss the advances of our knowledge of nuclear localization of RTKs and their novel functions in the nucleus and describe their implications in cancer therapy.",
keywords = "c-Met, DNA repair, Drug- resistance, EGFR, FGFR, Gene transcription, IGF1R, rRNA biogenesis, Tyrosine kinase inhibitor, VEGFR",
author = "Longfei Huo and Hsu, {Jennifer L.} and Hung, {Mien Chie}",
year = "2014",
doi = "10.1007/978-1-4614-8039-6_8",
language = "English (US)",
isbn = "9781461480389",
series = "Cancer Drug Discovery and Development",
publisher = "Humana Press Inc.",
pages = "189--229",
booktitle = "Nuclear Signaling Pathways and Targeting Transcription in Cancer",
}