Recommendations for supportive care and best supportive care in NCCN clinical practice guidelines for treatment of cancer: Differences between solid tumor and hematologic malignancy guidelines

Purpose: It is unclear how NCCN guidelines recommend “supportive care” and “best supportive care” in oncology practice. We examined the usage of “supportive care” and “best supportive care” in NCCN guidelines and compared between solid tumor and hematologic malignancy guidelines. Methods: We reviewed all updated NCCN Guidelines for Treatment of Cancer in October 2019. We documented the frequency of occurrence, definition, and timing of introduction of each term. We compared between solid tumor and hematologic malignancy guidelines. Results: We identified a total of 37 solid tumor and 16 hematologic guidelines. Thirty-seven (70%) guidelines mentioned “supportive care” and 36 (68%) mentioned “best supportive care.” Hematologic guidelines were significantly more likely than solid tumor guidelines to use the term “supportive care” (median occurrence 19 vs. 2; P = 0.001) and to describe “supportive care” as management of cancer-related complications (N = 11/15, 73% vs. N = 2/22, 9%; P < 0.001). Domains of specialist palliative care were infrequently mentioned (N = 10/37, 27%). In contrast, solid tumor guidelines were significantly more likely than hematologic guidelines to mention “best supportive care” (median occurrence 6 vs. 0; P = 0.016). This term was rarely defined and mostly used in the advanced disease setting. Conclusion: “Supportive care” and “best supportive care” were frequently used in NCCN guidelines, with significant variations in usage between solid tumor and hematologic oncologists. “Supportive care” was mostly limited to management of cancer-related complications and treatment adverse effects in NCCN guidelines, highlighting the need to go beyond the traditional biomedical model to more a patient-centered care model with greater integration of palliative care.