Abstract
Background: Patients who undergo pelvic floor resection as treatment for recurrent cancer following radiation therapy have increased rates of complications, particularly if permanent prosthetic mesh is used for reconstruction. Human acellular dermal matrix (HADM), commonly used for reconstruction in other torso locations, is associated with lower rates of complications (including infection, adhesions and cutaneous exposure) than synthetic mesh. We describe an effective technique to reconstruct the pelvic floor and perineum with HADM and thigh-based flaps following pelvic exenteration and radical vulvectomy. Case: A 75-year-old woman underwent radical resection of the pelvic floor and perineum to treat recurrent vulvar squamous cell carcinoma and osteoradionecrosis. The pelvic floor and perineal soft tissue defect were reconstructed with HADM (AlloDerm; LifeCell Corporation, Branchburg, NJ) and bilateral, thigh-based tissue flaps, respectively. Despite a large resection, previous irradiation therapy and bacterial contamination the wounds healed without complications. Conclusion: Reconstruction of pelvic floor defects using HADM is an option when wound conditions are unfavorable for the use of permanent prosthetic meshes.
Original language | English (US) |
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Pages (from-to) | 578-582 |
Number of pages | 5 |
Journal | Gynecologic oncology |
Volume | 107 |
Issue number | 3 |
DOIs | |
State | Published - Dec 2007 |
Keywords
- Alloderm
- Biocompatible materials
- Bioprosthetic mesh
- Carcinoma
- Gracilis
- Hernia
- Osteoradionecrosis
- Pelvic exentration
- Pelvic floor
- Perineum
- Polypropylenes
- Posterior thigh
- Prostheses and implants
- Radiotherapy
- Reconstructive surgical procedures
- Squamous cell
- Surgical flaps
- Surgical mesh
- VRAM
ASJC Scopus subject areas
- Oncology
- Obstetrics and Gynecology