TY - JOUR
T1 - Recurrences after surgical resection of intraductal papillary mucinous neoplasm of the pancreas
T2 - A single-center study of recurrence predictive factors
AU - Passot, Guillaume
AU - Lebeau, Roger
AU - Hervieu, Valérie
AU - Ponchon, Thierry
AU - Pilleul, Franck
AU - Adham, Mustapha
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/1
Y1 - 2012/1
N2 - Objective: The detection of intraductal papillary mucinous neoplasms (IPMN) has increased over the last decade, but still, management remains controversial. The main problems are their potential for malignancy and risk of recurrence. The purpose of this study was to determine the predictive factors of recurrence after surgical resection. Methods: All patients with IPMN who underwent pancreatectomy with curative intent were considered. Data were collected from a prospective base. Results: From 1994 to 2009, 104 patients underwent pancreatectomy. Twenty-one (20%) had recurrence, 15 on remnant pancreas (none on pancreatic cut surface) and 6 with distant metastases. Twelve patients had total pancreatectomy (1 awaiting surgery). Thirteen (38.2%) of 34 patients with invasive IPMN and 20 (25.9%) of 77 with main duct involvement (including combined type) had recurrence. In univariate analysis, American Society of Anesthesiologist score and histological and duct type had a significant impact on recurrence rate. In multivariate analysis, histological type (invasiveness) was the only significant predictive factor for recurrence. Conclusion: The risk of recurrence of IPMN after resection depends on the histological type. According to surgical margin, invasiveness, and the type of duct involved, we identified a high-risk group with invasive main duct lesion and a low-risk group with noninvasive branch duct lesion.
AB - Objective: The detection of intraductal papillary mucinous neoplasms (IPMN) has increased over the last decade, but still, management remains controversial. The main problems are their potential for malignancy and risk of recurrence. The purpose of this study was to determine the predictive factors of recurrence after surgical resection. Methods: All patients with IPMN who underwent pancreatectomy with curative intent were considered. Data were collected from a prospective base. Results: From 1994 to 2009, 104 patients underwent pancreatectomy. Twenty-one (20%) had recurrence, 15 on remnant pancreas (none on pancreatic cut surface) and 6 with distant metastases. Twelve patients had total pancreatectomy (1 awaiting surgery). Thirteen (38.2%) of 34 patients with invasive IPMN and 20 (25.9%) of 77 with main duct involvement (including combined type) had recurrence. In univariate analysis, American Society of Anesthesiologist score and histological and duct type had a significant impact on recurrence rate. In multivariate analysis, histological type (invasiveness) was the only significant predictive factor for recurrence. Conclusion: The risk of recurrence of IPMN after resection depends on the histological type. According to surgical margin, invasiveness, and the type of duct involved, we identified a high-risk group with invasive main duct lesion and a low-risk group with noninvasive branch duct lesion.
KW - intraductal papillary mucinous neoplasm
KW - recurrence
KW - surgery
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U2 - 10.1097/MPA.0b013e318222bc9c
DO - 10.1097/MPA.0b013e318222bc9c
M3 - Article
C2 - 22076564
AN - SCOPUS:84655169822
SN - 0885-3177
VL - 41
SP - 137
EP - 141
JO - Pancreas
JF - Pancreas
IS - 1
ER -