TY - JOUR
T1 - Recurrent HGNET-MN1 altered (astroblastoma MN1-altered) of the foramen magnum
T2 - Case report and molecular classification
AU - Gopakumar, Sricharan
AU - McDonald, Malcolm F.
AU - Sharma, Himanshu
AU - Tatsui, Claudio E.
AU - Fuller, Gregory N.
AU - Rao, Ganesh
N1 - Publisher Copyright:
©2022 Published by Scientific Scholar on behalf of Surgical Neurology International
PY - 2022
Y1 - 2022
N2 - Background: Astroblastoma is a rare primary brain tumor of unclear origin, often occurring in young patients less than 30-years-old. It typically arises supratentorially and is diagnosed based on histological features including vascular hyalinization and perivascular pseudorosettes. Recent molecular characterization of primary CNS high-grade neuroepithelial tumors with meningioma I alteration (HGNET-MN1) found that HGNET-MN1 and tumors with morphological signatures of astroblastoma clustered together. Further analysis revealed such astroblastomas have MN1 alteration and the 2021 WHO classification of tumors of the CNS now recognizes astroblastoma MN1altered as a new entity. Case Description: Here, we present the case of a 36-year-old right-handed woman with recurrent low-grade astroblastoma in the cervicomedullary junction. The patient presented with worsening motor and sensory deficits of her upper extremities, pain, ataxia, visual disturbance, and nausea. Due to extensive recurrence and neurological symptoms, the patient underwent reoperation. Conclusion: We review a rare case of recurrent astroblastoma in the foramen magnum in light of new relevant literature about tumor biology and prognostic significance of the new classification of astroblastoma MN1-altered.
AB - Background: Astroblastoma is a rare primary brain tumor of unclear origin, often occurring in young patients less than 30-years-old. It typically arises supratentorially and is diagnosed based on histological features including vascular hyalinization and perivascular pseudorosettes. Recent molecular characterization of primary CNS high-grade neuroepithelial tumors with meningioma I alteration (HGNET-MN1) found that HGNET-MN1 and tumors with morphological signatures of astroblastoma clustered together. Further analysis revealed such astroblastomas have MN1 alteration and the 2021 WHO classification of tumors of the CNS now recognizes astroblastoma MN1altered as a new entity. Case Description: Here, we present the case of a 36-year-old right-handed woman with recurrent low-grade astroblastoma in the cervicomedullary junction. The patient presented with worsening motor and sensory deficits of her upper extremities, pain, ataxia, visual disturbance, and nausea. Due to extensive recurrence and neurological symptoms, the patient underwent reoperation. Conclusion: We review a rare case of recurrent astroblastoma in the foramen magnum in light of new relevant literature about tumor biology and prognostic significance of the new classification of astroblastoma MN1-altered.
KW - Astroblastoma
KW - Foramen magnum
KW - MN1-altered
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U2 - 10.25259/SNI_1208_2021
DO - 10.25259/SNI_1208_2021
M3 - Article
C2 - 35509530
AN - SCOPUS:85128272040
SN - 2152-7806
VL - 13
JO - Surgical Neurology International
JF - Surgical Neurology International
M1 - 139
ER -