Recurrent oral cavity cancer: Patterns of failure after salvage multimodality therapy

Sean R. Quinlan–Davidson; William H. Morrison; Jeffrey N. Myers; Gary B. Gunn; William N. William; Beth M. Beadle; Heath D. Skinner; Ann M. Gillenwater; Steven J. Frank; Jack Phan; Faye M. Johnson; Clifton D. Fuller; Mark E. Zafereo; David I. Rosenthal; Adam S. Garden

doi:10.1002/hed.24666

Recurrent oral cavity cancer: Patterns of failure after salvage multimodality therapy

Sean R. Quinlan–Davidson, William H. Morrison, Jeffrey N. Myers, Gary B. Gunn, William N. William, Beth M. Beadle, Heath D. Skinner, Ann M. Gillenwater, Steven J. Frank, Jack Phan, Faye M. Johnson, Clifton D. Fuller, Mark E. Zafereo, David I. Rosenthal, Adam S. Garden

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16 Scopus citations

Abstract

Background: We focused on a cohort of radiation naïve patients who had recurrent oral cavity cancer (recurrent OCC) to assess their outcomes with salvage multimodal therapy. Methods: A retrospective single institutional study was performed of patients with recurrent OCC. Disease recurrence and survival outcomes were assessed. Results: Seventy-eight patients were analyzed. All patients had salvage surgery and intensity-modulated radiotherapy (IMRT) and 74% had chemotherapy. Five-year overall survival, recurrence-free survival, and locoregional control rates were 59%, 60%, and 74%, respectively. Conclusion: Outcomes of radiation naïve patients with recurrent OCC are fair, and seem similar with patients with locally advanced nonrecurrent OCC treated with multimodal therapy.

Original language	English (US)
Pages (from-to)	633-638
Number of pages	6
Journal	Head and Neck
Volume	39
Issue number	4
DOIs	https://doi.org/10.1002/hed.24666
State	Published - Apr 1 2017

Keywords

early stage
intensity-modulated radiotherapy (IMRT)
oral cavity cancer
radiotherapy
salvage

ASJC Scopus subject areas

Otorhinolaryngology

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Quinlan–Davidson, S. R., Morrison, W. H., Myers, J. N., Gunn, G. B., William, W. N., Beadle, B. M., Skinner, H. D., Gillenwater, A. M., Frank, S. J., Phan, J., Johnson, F. M., Fuller, C. D., Zafereo, M. E., Rosenthal, D. I., & Garden, A. S. (2017). Recurrent oral cavity cancer: Patterns of failure after salvage multimodality therapy. Head and Neck, 39(4), 633-638. https://doi.org/10.1002/hed.24666

Quinlan–Davidson, SR, Morrison, WH , Myers, JN , Gunn, GB, William, WN, Beadle, BM, Skinner, HD, Gillenwater, AM , Frank, SJ , Phan, J , Johnson, FM , Fuller, CD , Zafereo, ME , Rosenthal, DI & Garden, AS 2017, 'Recurrent oral cavity cancer: Patterns of failure after salvage multimodality therapy', Head and Neck, vol. 39, no. 4, pp. 633-638. https://doi.org/10.1002/hed.24666

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title = "Recurrent oral cavity cancer: Patterns of failure after salvage multimodality therapy",

abstract = "Background: We focused on a cohort of radiation na{\"i}ve patients who had recurrent oral cavity cancer (recurrent OCC) to assess their outcomes with salvage multimodal therapy. Methods: A retrospective single institutional study was performed of patients with recurrent OCC. Disease recurrence and survival outcomes were assessed. Results: Seventy-eight patients were analyzed. All patients had salvage surgery and intensity-modulated radiotherapy (IMRT) and 74% had chemotherapy. Five-year overall survival, recurrence-free survival, and locoregional control rates were 59%, 60%, and 74%, respectively. Conclusion: Outcomes of radiation na{\"i}ve patients with recurrent OCC are fair, and seem similar with patients with locally advanced nonrecurrent OCC treated with multimodal therapy.",

keywords = "early stage, intensity-modulated radiotherapy (IMRT), oral cavity cancer, radiotherapy, salvage",

author = "Quinlan–Davidson, {Sean R.} and Morrison, {William H.} and Myers, {Jeffrey N.} and Gunn, {Gary B.} and William, {William N.} and Beadle, {Beth M.} and Skinner, {Heath D.} and Gillenwater, {Ann M.} and Frank, {Steven J.} and Jack Phan and Johnson, {Faye M.} and Fuller, {Clifton D.} and Zafereo, {Mark E.} and Rosenthal, {David I.} and Garden, {Adam S.}",

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year = "2017",

month = apr,

day = "1",

doi = "10.1002/hed.24666",

language = "English (US)",

volume = "39",

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T1 - Recurrent oral cavity cancer

T2 - Patterns of failure after salvage multimodality therapy

AU - Quinlan–Davidson, Sean R.

AU - Morrison, William H.

AU - Myers, Jeffrey N.

AU - Gunn, Gary B.

AU - William, William N.

AU - Beadle, Beth M.

AU - Skinner, Heath D.

AU - Gillenwater, Ann M.

AU - Frank, Steven J.

AU - Phan, Jack

AU - Johnson, Faye M.

AU - Fuller, Clifton D.

AU - Zafereo, Mark E.

AU - Rosenthal, David I.

AU - Garden, Adam S.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Background: We focused on a cohort of radiation naïve patients who had recurrent oral cavity cancer (recurrent OCC) to assess their outcomes with salvage multimodal therapy. Methods: A retrospective single institutional study was performed of patients with recurrent OCC. Disease recurrence and survival outcomes were assessed. Results: Seventy-eight patients were analyzed. All patients had salvage surgery and intensity-modulated radiotherapy (IMRT) and 74% had chemotherapy. Five-year overall survival, recurrence-free survival, and locoregional control rates were 59%, 60%, and 74%, respectively. Conclusion: Outcomes of radiation naïve patients with recurrent OCC are fair, and seem similar with patients with locally advanced nonrecurrent OCC treated with multimodal therapy.

AB - Background: We focused on a cohort of radiation naïve patients who had recurrent oral cavity cancer (recurrent OCC) to assess their outcomes with salvage multimodal therapy. Methods: A retrospective single institutional study was performed of patients with recurrent OCC. Disease recurrence and survival outcomes were assessed. Results: Seventy-eight patients were analyzed. All patients had salvage surgery and intensity-modulated radiotherapy (IMRT) and 74% had chemotherapy. Five-year overall survival, recurrence-free survival, and locoregional control rates were 59%, 60%, and 74%, respectively. Conclusion: Outcomes of radiation naïve patients with recurrent OCC are fair, and seem similar with patients with locally advanced nonrecurrent OCC treated with multimodal therapy.

KW - early stage

KW - intensity-modulated radiotherapy (IMRT)

KW - oral cavity cancer

KW - radiotherapy

KW - salvage

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Recurrent oral cavity cancer: Patterns of failure after salvage multimodality therapy

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