TY - JOUR
T1 - Reduced Intensity Conditioning for Allogeneic Stem Cell Transplantation in Relapsed and Refractory Hodgkin Lymphoma
T2 - Where Do We Stand?
AU - Anderlini, Paolo
AU - Champlin, Richard E.
PY - 2006/6
Y1 - 2006/6
N2 - Allogeneic stem cell transplantation following myeloablative conditioning in relapsed and refractory Hodgkin lymphoma (HL) has been associated with substantial transplant-related morbidity and mortality, as well as high relapse rates. Despite these problems, a minority of patients have experienced long-term remissions and presumably cure. As in other hematologic malignancies, reduced intensity conditioning (RIC) has now been introduced as an alternative approach. The published experience with RIC in HL patients is reviewed. While early transplant-related morbidity and mortality seem markedly reduced and preliminary data on patient outcome look promising, this remains a challenging area and additional work will be needed to clearly define the role of RIC in relapsed and refractory HL.
AB - Allogeneic stem cell transplantation following myeloablative conditioning in relapsed and refractory Hodgkin lymphoma (HL) has been associated with substantial transplant-related morbidity and mortality, as well as high relapse rates. Despite these problems, a minority of patients have experienced long-term remissions and presumably cure. As in other hematologic malignancies, reduced intensity conditioning (RIC) has now been introduced as an alternative approach. The published experience with RIC in HL patients is reviewed. While early transplant-related morbidity and mortality seem markedly reduced and preliminary data on patient outcome look promising, this remains a challenging area and additional work will be needed to clearly define the role of RIC in relapsed and refractory HL.
KW - Allogeneic stem cell transplantation
KW - Reduced-intensity conditioning
UR - http://www.scopus.com/inward/record.url?scp=33646785047&partnerID=8YFLogxK
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U2 - 10.1016/j.bbmt.2006.03.013
DO - 10.1016/j.bbmt.2006.03.013
M3 - Review article
C2 - 16737932
AN - SCOPUS:33646785047
SN - 1083-8791
VL - 12
SP - 599
EP - 602
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 6
ER -