Reengineered epipodophyllotoxin

Igor V. Magedov; Nikolai M. Evdokimov; Menuka Karki; Amanda S. Peretti; Dustin T. Lima; Liliya V. Frolova; Mary R. Reisenauer; Anntherese E. Romero; Paul Tongwa; Alexandr Fonari; Jeff Altig; Snezna Rogelj; Alexander Kornienko

doi:10.1039/c2cc35044k

Reengineered epipodophyllotoxin

Igor V. Magedov, Nikolai M. Evdokimov, Menuka Karki, Amanda S. Peretti, Dustin T. Lima, Liliya V. Frolova, Mary R. Reisenauer, Anntherese E. Romero, Paul Tongwa, Alexandr Fonari, Jeff Altig, Snezna Rogelj, Alexander Kornienko

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.

Original language	English (US)
Pages (from-to)	10416-10418
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	84
DOIs	https://doi.org/10.1039/c2cc35044k
State	Published - Sep 26 2012
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c2cc35044k

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title = "Reengineered epipodophyllotoxin",

abstract = "A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.",

author = "Magedov, {Igor V.} and Evdokimov, {Nikolai M.} and Menuka Karki and Peretti, {Amanda S.} and Lima, {Dustin T.} and Frolova, {Liliya V.} and Reisenauer, {Mary R.} and Romero, {Anntherese E.} and Paul Tongwa and Alexandr Fonari and Jeff Altig and Snezna Rogelj and Alexander Kornienko",

year = "2012",

month = sep,

day = "26",

doi = "10.1039/c2cc35044k",

language = "English (US)",

volume = "48",

pages = "10416--10418",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

number = "84",

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TY - JOUR

T1 - Reengineered epipodophyllotoxin

AU - Magedov, Igor V.

AU - Evdokimov, Nikolai M.

AU - Karki, Menuka

AU - Peretti, Amanda S.

AU - Lima, Dustin T.

AU - Frolova, Liliya V.

AU - Reisenauer, Mary R.

AU - Romero, Anntherese E.

AU - Tongwa, Paul

AU - Fonari, Alexandr

AU - Altig, Jeff

AU - Rogelj, Snezna

AU - Kornienko, Alexander

PY - 2012/9/26

Y1 - 2012/9/26

N2 - A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.

AB - A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.

UR - http://www.scopus.com/inward/record.url?scp=84866925292&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866925292&partnerID=8YFLogxK

U2 - 10.1039/c2cc35044k

DO - 10.1039/c2cc35044k

M3 - Article

C2 - 22986348

AN - SCOPUS:84866925292

SN - 1359-7345

VL - 48

SP - 10416

EP - 10418

JO - Chemical Communications

JF - Chemical Communications

IS - 84

ER -

Reengineered epipodophyllotoxin

Abstract

ASJC Scopus subject areas

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