TY - JOUR
T1 - Reflectance spectroscopy for in vivo characterization of ovarian tissue
AU - Utzinger, Urs
AU - Brewer, Molly
AU - Silva, Elvio
AU - Gershenson, David
AU - Blast, Robert C.
AU - Follen, Michele
AU - Richards-Kortum, Rebecca
PY - 2001
Y1 - 2001
N2 - Background and Objective: To explore whether reflectance spectroscopy can differentiate normal ovary, benign neoplasms, and ovarian cancer. Study Design/Materials and Methods: Reflectance spectra (390-600 nm) were measured at three source-detector separations (SDS) in vivo at 64 sites in 16 patients undergoing oophorectomy. Parameters with largest statistical differences were identified. Based on these parameters algorithms were developed and evaluated. Results: Promising parameters were the reflectance intensity from 540 to 580 nm (SDS, 1.1 mm), the slope of the reflectance spectrum from 490 to 520 nm (SDS, 1.1 mm), the slope from 510 to 530 nm (SDS, 2.1 mm), and the slope from 510 to 530 (SDS, 3 mm). Average sensitivity and specificity were 86 ± 6% and 79 ± 5% to separate normal ovary from benign neoplasms and cancers. Average sensitivity and specificity were 86 ± 4% and 80 ± 8% to separate ovarian cancers from benign neoplasms and normal ovary. Conclusion: Reflectance spectroscopy should be further investigated for ovarian cancer screening. 2001 Wiley-Liss, Inc.
AB - Background and Objective: To explore whether reflectance spectroscopy can differentiate normal ovary, benign neoplasms, and ovarian cancer. Study Design/Materials and Methods: Reflectance spectra (390-600 nm) were measured at three source-detector separations (SDS) in vivo at 64 sites in 16 patients undergoing oophorectomy. Parameters with largest statistical differences were identified. Based on these parameters algorithms were developed and evaluated. Results: Promising parameters were the reflectance intensity from 540 to 580 nm (SDS, 1.1 mm), the slope of the reflectance spectrum from 490 to 520 nm (SDS, 1.1 mm), the slope from 510 to 530 nm (SDS, 2.1 mm), and the slope from 510 to 530 (SDS, 3 mm). Average sensitivity and specificity were 86 ± 6% and 79 ± 5% to separate normal ovary from benign neoplasms and cancers. Average sensitivity and specificity were 86 ± 4% and 80 ± 8% to separate ovarian cancers from benign neoplasms and normal ovary. Conclusion: Reflectance spectroscopy should be further investigated for ovarian cancer screening. 2001 Wiley-Liss, Inc.
KW - Ovarian cancer detection
KW - Reflectance spectroscopy
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U2 - 10.1002/1096-9101(2001)28:1<56::AID-LSM1017>3.0.CO;2-L
DO - 10.1002/1096-9101(2001)28:1<56::AID-LSM1017>3.0.CO;2-L
M3 - Article
C2 - 11430444
AN - SCOPUS:0035165313
SN - 0196-8092
VL - 28
SP - 56
EP - 66
JO - Lasers in Surgery and Medicine
JF - Lasers in Surgery and Medicine
IS - 1
ER -