Regional anesthesia/analgesia and the risk of cancer recurrence and mortality after prostatectomy: a meta-analysis

Brenda M. Lee; Vinny Singh Ghotra; Jose A. Karam; Mike Hernandez; Greg Pratt; Juan P. Cata

doi:10.2217/pmt.15.30

Regional anesthesia/analgesia and the risk of cancer recurrence and mortality after prostatectomy: a meta-analysis

Brenda M. Lee, Vinny Singh Ghotra, Jose A. Karam, Mike Hernandez, Greg Pratt, Juan P. Cata

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

AIMS: To determine whether the use neuraxial anesthesia/analgesia is associated with longer biochemical recurrence-free survival (BRFS) and overall survival (OS) after radical prostatectomy.

METHODS: Ten studies were included in the meta-analysis. A random-effects model was used to estimate the hazard ratios (HRs).

RESULTS: The HR for BRFS was 1.02 (95% CI: 0.91-1.15) for all studies and 1.08 (95% CI: 0.91-1.15) for those that included propensity score matching. For OS, the HR across all studies was 0.91 (95% CI: 0.7-1.15) and 0.81 (95% CI: 0.68-0.96; p = 0.016) for those reporting propensity score matching.

CONCLUSION: The anesthetic technique used during oncologic prostatectomy surgery is not associated with longer BRFS. By contrast, the use of regional analgesia appears to improve OS.

Original language	English (US)
Pages (from-to)	387-395
Number of pages	9
Journal	Pain Management
Volume	5
Issue number	5
DOIs	https://doi.org/10.2217/pmt.15.30
State	Published - Sep 1 2015

Keywords

biochemical recurrence-free survival
overall survival
prostate cancer
regional anesthesia

ASJC Scopus subject areas

General Medicine

MD Anderson CCSG core facilities

Biostatistics Resource Group

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10.2217/pmt.15.30

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title = "Regional anesthesia/analgesia and the risk of cancer recurrence and mortality after prostatectomy: a meta-analysis",

abstract = "AIMS: To determine whether the use neuraxial anesthesia/analgesia is associated with longer biochemical recurrence-free survival (BRFS) and overall survival (OS) after radical prostatectomy.METHODS: Ten studies were included in the meta-analysis. A random-effects model was used to estimate the hazard ratios (HRs).RESULTS: The HR for BRFS was 1.02 (95% CI: 0.91-1.15) for all studies and 1.08 (95% CI: 0.91-1.15) for those that included propensity score matching. For OS, the HR across all studies was 0.91 (95% CI: 0.7-1.15) and 0.81 (95% CI: 0.68-0.96; p = 0.016) for those reporting propensity score matching.CONCLUSION: The anesthetic technique used during oncologic prostatectomy surgery is not associated with longer BRFS. By contrast, the use of regional analgesia appears to improve OS.",

keywords = "biochemical recurrence-free survival, overall survival, prostate cancer, regional anesthesia",

author = "Lee, {Brenda M.} and {Singh Ghotra}, Vinny and Karam, {Jose A.} and Mike Hernandez and Greg Pratt and Cata, {Juan P.}",

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doi = "10.2217/pmt.15.30",

language = "English (US)",

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T1 - Regional anesthesia/analgesia and the risk of cancer recurrence and mortality after prostatectomy

T2 - a meta-analysis

AU - Lee, Brenda M.

AU - Singh Ghotra, Vinny

AU - Karam, Jose A.

AU - Hernandez, Mike

AU - Pratt, Greg

AU - Cata, Juan P.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - AIMS: To determine whether the use neuraxial anesthesia/analgesia is associated with longer biochemical recurrence-free survival (BRFS) and overall survival (OS) after radical prostatectomy.METHODS: Ten studies were included in the meta-analysis. A random-effects model was used to estimate the hazard ratios (HRs).RESULTS: The HR for BRFS was 1.02 (95% CI: 0.91-1.15) for all studies and 1.08 (95% CI: 0.91-1.15) for those that included propensity score matching. For OS, the HR across all studies was 0.91 (95% CI: 0.7-1.15) and 0.81 (95% CI: 0.68-0.96; p = 0.016) for those reporting propensity score matching.CONCLUSION: The anesthetic technique used during oncologic prostatectomy surgery is not associated with longer BRFS. By contrast, the use of regional analgesia appears to improve OS.

AB - AIMS: To determine whether the use neuraxial anesthesia/analgesia is associated with longer biochemical recurrence-free survival (BRFS) and overall survival (OS) after radical prostatectomy.METHODS: Ten studies were included in the meta-analysis. A random-effects model was used to estimate the hazard ratios (HRs).RESULTS: The HR for BRFS was 1.02 (95% CI: 0.91-1.15) for all studies and 1.08 (95% CI: 0.91-1.15) for those that included propensity score matching. For OS, the HR across all studies was 0.91 (95% CI: 0.7-1.15) and 0.81 (95% CI: 0.68-0.96; p = 0.016) for those reporting propensity score matching.CONCLUSION: The anesthetic technique used during oncologic prostatectomy surgery is not associated with longer BRFS. By contrast, the use of regional analgesia appears to improve OS.

KW - biochemical recurrence-free survival

KW - overall survival

KW - prostate cancer

KW - regional anesthesia

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Regional anesthesia/analgesia and the risk of cancer recurrence and mortality after prostatectomy: a meta-analysis

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

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