Regulates paclitaxel sensitivity in ovarian cancer cells by modulating AKT ativation, p21Cip1- and p27Kip1-mediated G1 cell cycle arrest and apoptosis

Agriculture & Biology

• ovarian neoplasms 97%
• cell cycle checkpoints 88%
• cyclin-dependent kinase 87%
• paclitaxel 85%
• apoptosis 62%
• neoplasm cells 62%
• small interfering RNA 13%
• cell lines 8%
• caspase-3 6%
• threonine 5%
• cell death 5%
• cell viability 5%
• serine 5%
• cell cycle 5%
• phosphotransferases (kinases) 4%
• growth retardation 4%
• cell growth 4%
• neoplasms 4%
• staining 4%
• mice 3%
• tissues 2%
• proteins 1%

Medicine & Life Sciences

• Cyclin-Dependent Kinase 5 100%
• G1 Phase Cell Cycle Checkpoints 88%
• Paclitaxel 68%
• Ovarian Neoplasms 61%
• Apoptosis 41%
• human CDK5 protein 15%
• Mouse Cdk5 protein 13%
• Heterografts 12%
• Small Interfering RNA 11%
• Growth 10%
• Cell Line 8%
• Protein-Serine-Threonine Kinases 7%
• Survival 7%
• Human Activities 6%
• Cell Cycle Checkpoints 6%
• Neoplasms 6%
• Caspase 3 6%
• Cell Cycle 5%
• Cell Survival 5%
• Cell Death 5%
• Up-Regulation 4%
• Staining and Labeling 4%
• Proteins 2%
• Therapeutics 2%

Chemistry

• Growth Inhibition 10%
• Apoptotic 9%
• Threonine 9%
• Microarrays 9%
• Cell Death 9%
• Cell Viability 8%
• Protein 3%