Regulating actin-filament dynamics in vivo

Hui Chen; Barbara W. Bernstein; James R. Bamburg

doi:10.1016/S0968-0004(99)01511-X

Regulating actin-filament dynamics in vivo

Hui Chen, Barbara W. Bernstein, James R. Bamburg

Research output: Contribution to journal › Review article › peer-review

223 Scopus citations

Abstract

The assembly and disassembly (i.e. turnover) of actin filaments in response to extracellular signals underlie a wide variety of basic cellular processes such as cell division, endocytosis and motility. The bulk turnover of subunits is 100-200 times faster in cells than with pure actin, suggesting a complex regulation in vivo. Significant progress has been made recently in identifying and clarifying the roles of several cellular proteins that coordinately regulate actin-filament turnover. Copyright (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	19-23
Number of pages	5
Journal	Trends in Biochemical Sciences
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/S0968-0004(99)01511-X
State	Published - Jan 1 2000
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology

Access to Document

10.1016/S0968-0004(99)01511-X

Cite this

@article{add1d9f222b049c4988c44b70b8f89a1,

title = "Regulating actin-filament dynamics in vivo",

abstract = "The assembly and disassembly (i.e. turnover) of actin filaments in response to extracellular signals underlie a wide variety of basic cellular processes such as cell division, endocytosis and motility. The bulk turnover of subunits is 100-200 times faster in cells than with pure actin, suggesting a complex regulation in vivo. Significant progress has been made recently in identifying and clarifying the roles of several cellular proteins that coordinately regulate actin-filament turnover. Copyright (C) 2000 Elsevier Science Ltd.",

author = "Hui Chen and Bernstein, {Barbara W.} and Bamburg, {James R.}",

note = "Funding Information: We apologize to the many authors who made original contributions to the findings reported here but whose work was not directly cited due to editorial restrictions on the number of references. Recent reviews have been cited in place of many original references. We would like to thank T. Pollard, L. Blanchoin and K. Okada for many helpful discussions, and the NIH (grants GM35126 and GM54004 to J.R.B.) and the March of Dimes Birth Defects Foundation (6-FY98-92 to B.W.B.) for their support.",

year = "2000",

month = jan,

day = "1",

doi = "10.1016/S0968-0004(99)01511-X",

language = "English (US)",

volume = "25",

pages = "19--23",

journal = "Trends in Biochemical Sciences",

issn = "0968-0004",

publisher = "Elsevier Limited",

number = "1",

}

TY - JOUR

T1 - Regulating actin-filament dynamics in vivo

AU - Chen, Hui

AU - Bernstein, Barbara W.

AU - Bamburg, James R.

N1 - Funding Information: We apologize to the many authors who made original contributions to the findings reported here but whose work was not directly cited due to editorial restrictions on the number of references. Recent reviews have been cited in place of many original references. We would like to thank T. Pollard, L. Blanchoin and K. Okada for many helpful discussions, and the NIH (grants GM35126 and GM54004 to J.R.B.) and the March of Dimes Birth Defects Foundation (6-FY98-92 to B.W.B.) for their support.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - The assembly and disassembly (i.e. turnover) of actin filaments in response to extracellular signals underlie a wide variety of basic cellular processes such as cell division, endocytosis and motility. The bulk turnover of subunits is 100-200 times faster in cells than with pure actin, suggesting a complex regulation in vivo. Significant progress has been made recently in identifying and clarifying the roles of several cellular proteins that coordinately regulate actin-filament turnover. Copyright (C) 2000 Elsevier Science Ltd.

AB - The assembly and disassembly (i.e. turnover) of actin filaments in response to extracellular signals underlie a wide variety of basic cellular processes such as cell division, endocytosis and motility. The bulk turnover of subunits is 100-200 times faster in cells than with pure actin, suggesting a complex regulation in vivo. Significant progress has been made recently in identifying and clarifying the roles of several cellular proteins that coordinately regulate actin-filament turnover. Copyright (C) 2000 Elsevier Science Ltd.

UR - http://www.scopus.com/inward/record.url?scp=0033977699&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033977699&partnerID=8YFLogxK

U2 - 10.1016/S0968-0004(99)01511-X

DO - 10.1016/S0968-0004(99)01511-X

M3 - Review article

C2 - 10637608

AN - SCOPUS:0033977699

SN - 0968-0004

VL - 25

SP - 19

EP - 23

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 1

ER -

Regulating actin-filament dynamics in vivo

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this