Regulation and function of proinflammatory TH17 cells

Gustavo J. Martinez; Roza I. Nurieva; Xuexian O. Yang; Chen Dong

doi:10.1196/annals.1443.021

Regulation and function of proinflammatory TH17 cells

Gustavo J. Martinez, Roza I. Nurieva, Xuexian O. Yang, Chen Dong

Immunology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

168 Scopus citations

Abstract

Naïve CD4⁺ helper T (TH) cells, upon activation by antigen-presenting cells (APC), differentiate into different types of effector cells that are characterized by their distinct cytokine production profiles and immune regulatory functions. In addition to TH1 and TH2 cells, a third subset of effector TH cells has recently been described and termed TH17. Since their identification, TH17 cells have emerged as crucial players in infectious, inflammatory, and autoimmune diseases, and cancer. In this review, we summarize the latest discoveries on the cytokine-mediated regulation and transcriptional programming of TH17 cells and their roles in different immune responses and diseases.

Original language	English (US)
Title of host publication	The Year in Immunology 2008
Publisher	Blackwell Publishing Inc.
Pages	188-211
Number of pages	24
ISBN (Print)	9781573317290
DOIs	https://doi.org/10.1196/annals.1443.021
State	Published - Nov 2008

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1143
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

Keywords

Antigen-presenting cells
CD4 T helper
Pro-inflammatory TH17 cells

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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10.1196/annals.1443.021

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abstract = "Na{\"i}ve CD4+ helper T (TH) cells, upon activation by antigen-presenting cells (APC), differentiate into different types of effector cells that are characterized by their distinct cytokine production profiles and immune regulatory functions. In addition to TH1 and TH2 cells, a third subset of effector TH cells has recently been described and termed TH17. Since their identification, TH17 cells have emerged as crucial players in infectious, inflammatory, and autoimmune diseases, and cancer. In this review, we summarize the latest discoveries on the cytokine-mediated regulation and transcriptional programming of TH17 cells and their roles in different immune responses and diseases.",

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AU - Nurieva, Roza I.

AU - Yang, Xuexian O.

AU - Dong, Chen

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AB - Naïve CD4+ helper T (TH) cells, upon activation by antigen-presenting cells (APC), differentiate into different types of effector cells that are characterized by their distinct cytokine production profiles and immune regulatory functions. In addition to TH1 and TH2 cells, a third subset of effector TH cells has recently been described and termed TH17. Since their identification, TH17 cells have emerged as crucial players in infectious, inflammatory, and autoimmune diseases, and cancer. In this review, we summarize the latest discoveries on the cytokine-mediated regulation and transcriptional programming of TH17 cells and their roles in different immune responses and diseases.

KW - Antigen-presenting cells

KW - CD4 T helper

KW - Pro-inflammatory TH17 cells

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M3 - Chapter

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ER -

Regulation and function of proinflammatory TH17 cells

Abstract

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Keywords

ASJC Scopus subject areas

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