TY - JOUR
T1 - Regulation and role of CAMKK2 in prostate cancer
AU - Pulliam, Thomas L.
AU - Goli, Pavithr
AU - Awad, Dominik
AU - Lin, Chenchu
AU - Wilkenfeld, Sandi R.
AU - Frigo, Daniel E.
N1 - Publisher Copyright:
© 2022, Springer Nature Limited.
PY - 2022/6
Y1 - 2022/6
N2 - In 2011, CAMKK2, the gene encoding calcium/calmodulin-dependent kinase kinase 2 (CAMKK2), was demonstrated to be a direct target of the androgen receptor and a driver of prostate cancer progression. Results from multiple independent studies have confirmed these findings and demonstrated the potential role of CAMKK2 as a clinical biomarker and therapeutic target in advanced prostate cancer using a variety of preclinical models. Drug development efforts targeting CAMKK2 have begun accordingly. CAMKK2 regulation can vary across disease stages, which might have important implications in the use of CAMKK2 as a biomarker. Moreover, new non-cell-autonomous roles for CAMKK2 that could affect tumorigenesis, metastasis and possible comorbidities linked to disease and treatment have emerged and could present novel treatment opportunities for prostate cancer.
AB - In 2011, CAMKK2, the gene encoding calcium/calmodulin-dependent kinase kinase 2 (CAMKK2), was demonstrated to be a direct target of the androgen receptor and a driver of prostate cancer progression. Results from multiple independent studies have confirmed these findings and demonstrated the potential role of CAMKK2 as a clinical biomarker and therapeutic target in advanced prostate cancer using a variety of preclinical models. Drug development efforts targeting CAMKK2 have begun accordingly. CAMKK2 regulation can vary across disease stages, which might have important implications in the use of CAMKK2 as a biomarker. Moreover, new non-cell-autonomous roles for CAMKK2 that could affect tumorigenesis, metastasis and possible comorbidities linked to disease and treatment have emerged and could present novel treatment opportunities for prostate cancer.
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U2 - 10.1038/s41585-022-00588-z
DO - 10.1038/s41585-022-00588-z
M3 - Article
C2 - 35474107
AN - SCOPUS:85131771219
SN - 1759-4812
VL - 19
SP - 367
EP - 380
JO - Nature Reviews Urology
JF - Nature Reviews Urology
IS - 6
ER -