TY - JOUR
T1 - Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS)
AU - Simpson, Tyler R.
AU - Quezada, Sergio A.
AU - Allison, James P.
N1 - Funding Information:
We would like to thank Tsvetelina P. Hoang, Xingxing Zang, and Alejandro Sepulveda for critical review of this manuscript. Tyler R. Simpson is supported by a Canadian Institutes of Health Doctoral Research Award. Sergio A. Quezada is a Research Fellow funded by the Irvington Institute Fellowship Program of the Cancer Research Institute, USA, and a junior member of the Millennium Nucleus on Immunology and Immunotherapy, Pontifícia Universidad Católica de Chile. James P. Allison is an investigator of the Howard Hughes Medical Institute and holds the David H Koch Chair in Immunologic Studies at Memorial Sloan-Kettering Cancer Center.
PY - 2010/6
Y1 - 2010/6
N2 - Inducible costimulator (ICOS), a member of the CD28 family of costimulatory molecules, is upregulated on the surface of T cells following T cell activation and upon binding to its ligand (ICOSL), initiates a cascade of events that can shape key aspects of the immune response. Although initial studies focused on determining the role of ICOS in Th1 versus T helper 2 (Th2) responses, new insights into its biology have revealed the contribution of ICOS to germinal center formation and isotype switching, as well as its relevance to the fate and function of effector and regulatory CD4+ T cells in the response against self (i.e., tumors) and non-self (i.e., bacterial, worm, and viral infections). This multiplicity of roles positions ICOS at the center of attention for immunotherapy where manipulation of this pathway could lead to novel approaches in the treatment of human diseases.
AB - Inducible costimulator (ICOS), a member of the CD28 family of costimulatory molecules, is upregulated on the surface of T cells following T cell activation and upon binding to its ligand (ICOSL), initiates a cascade of events that can shape key aspects of the immune response. Although initial studies focused on determining the role of ICOS in Th1 versus T helper 2 (Th2) responses, new insights into its biology have revealed the contribution of ICOS to germinal center formation and isotype switching, as well as its relevance to the fate and function of effector and regulatory CD4+ T cells in the response against self (i.e., tumors) and non-self (i.e., bacterial, worm, and viral infections). This multiplicity of roles positions ICOS at the center of attention for immunotherapy where manipulation of this pathway could lead to novel approaches in the treatment of human diseases.
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U2 - 10.1016/j.coi.2010.01.001
DO - 10.1016/j.coi.2010.01.001
M3 - Review article
C2 - 20116985
AN - SCOPUS:77952348017
SN - 0952-7915
VL - 22
SP - 326
EP - 332
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 3
ER -