Regulation of dendritic cell development by STATs

Haiyan S. Li; Stephanie S. Watowich

doi:10.1007/978-3-7091-0891-8_11

Regulation of dendritic cell development by STATs

Haiyan S. Li, Stephanie S. Watowich

Immunology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Dendritic cells (DCs) serve as a critical link between the innate and adaptive immune responses due to their ability to sense pathogens and respond by activating adaptive immune cell types. Delineating the molecular control of DC development will provide important information about the generation of natural immunity as well as approaches to regulate DCs in clinical settings. DCs are generated from hematopoietic stem cells through specialized progenitor subsets in response to cytokine and transcriptional cues, with FMS-like tyrosine kinase 3 ligand (Flt3L) and Flt3L receptor (Flt3) signaling providing a major pathway supporting homeostatic DC generation. Recent work has indicated that granulocyte-macrophage colony-stimulating factor (GM-CSF) and type I interferons (IFNs) also play important roles in regulating DC subset production. Here we review new insight into the mechanisms by which cytokine-activated STAT proteins control the DC developmental process.

Original language	English (US)
Title of host publication	Jak-Stat Signaling
Subtitle of host publication	From Basics to Disease
Publisher	Springer-Verlag Wien
Pages	169-186
Number of pages	18
ISBN (Electronic)	9783709108918
ISBN (Print)	370910890X, 9783709108901
DOIs	https://doi.org/10.1007/978-3-7091-0891-8_11
State	Published - Nov 1 2012

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-3-7091-0891-8_11

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Regulation of dendritic cell development by STATs

Abstract

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