Regulation of immune and autoimmune responses by ICOS-B7h interaction

Roza I. Nurieva

doi:10.1016/j.clim.2005.02.010

Regulation of immune and autoimmune responses by ICOS-B7h interaction

Roza I. Nurieva

Immunology

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Proper T cell activation and function are regulated by the innate immune system, importantly through positive and negative costimulatory molecules of the B7 superfamily. Inducible costimulator (ICOS) is expressed on T cells after T cell activation. A ligand for ICOS, B7h (also known as B7RP-1), is expressed on B cells and induced in nonlymphoid tissues by TNF-α. The wide distribution of B7h may play essential roles in different phases and types of immune function. In this review, we summarize the latest data about inducible costimulator and its receptor and their roles in regulation of immune and autoimmune responses.

Original language	English (US)
Pages (from-to)	19-25
Number of pages	7
Journal	Clinical Immunology
Volume	115
Issue number	1 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.clim.2005.02.010
State	Published - Apr 2005

Keywords

Collagen-induced arthritis
Costimulation
IL-17
NFATc1
T cells
c-Maf

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1016/j.clim.2005.02.010

Cite this

@article{3c57515011c14f4fbcaabc2337173144,

title = "Regulation of immune and autoimmune responses by ICOS-B7h interaction",

abstract = "Proper T cell activation and function are regulated by the innate immune system, importantly through positive and negative costimulatory molecules of the B7 superfamily. Inducible costimulator (ICOS) is expressed on T cells after T cell activation. A ligand for ICOS, B7h (also known as B7RP-1), is expressed on B cells and induced in nonlymphoid tissues by TNF-α. The wide distribution of B7h may play essential roles in different phases and types of immune function. In this review, we summarize the latest data about inducible costimulator and its receptor and their roles in regulation of immune and autoimmune responses.",

keywords = "Collagen-induced arthritis, Costimulation, IL-17, NFATc1, T cells, c-Maf",

author = "Nurieva, {Roza I.}",

note = "Funding Information: I thank my advisor Dr. Chen Dong for his support and help with manuscript preparation, many collaborators for scientific contribution, Caroline Bishop and Dr. Natalia Martin-Orozco for critical reading of the manuscript and the entire Dong Lab for discussion and help. My work is in part supported by a postdoctoral fellowship from Arthritis Foundation.",

year = "2005",

month = apr,

doi = "10.1016/j.clim.2005.02.010",

language = "English (US)",

volume = "115",

pages = "19--25",

journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Academic Press Inc.",

number = "1 SPEC. ISS.",

}

TY - JOUR

T1 - Regulation of immune and autoimmune responses by ICOS-B7h interaction

AU - Nurieva, Roza I.

N1 - Funding Information: I thank my advisor Dr. Chen Dong for his support and help with manuscript preparation, many collaborators for scientific contribution, Caroline Bishop and Dr. Natalia Martin-Orozco for critical reading of the manuscript and the entire Dong Lab for discussion and help. My work is in part supported by a postdoctoral fellowship from Arthritis Foundation.

PY - 2005/4

Y1 - 2005/4

N2 - Proper T cell activation and function are regulated by the innate immune system, importantly through positive and negative costimulatory molecules of the B7 superfamily. Inducible costimulator (ICOS) is expressed on T cells after T cell activation. A ligand for ICOS, B7h (also known as B7RP-1), is expressed on B cells and induced in nonlymphoid tissues by TNF-α. The wide distribution of B7h may play essential roles in different phases and types of immune function. In this review, we summarize the latest data about inducible costimulator and its receptor and their roles in regulation of immune and autoimmune responses.

AB - Proper T cell activation and function are regulated by the innate immune system, importantly through positive and negative costimulatory molecules of the B7 superfamily. Inducible costimulator (ICOS) is expressed on T cells after T cell activation. A ligand for ICOS, B7h (also known as B7RP-1), is expressed on B cells and induced in nonlymphoid tissues by TNF-α. The wide distribution of B7h may play essential roles in different phases and types of immune function. In this review, we summarize the latest data about inducible costimulator and its receptor and their roles in regulation of immune and autoimmune responses.

KW - Collagen-induced arthritis

KW - Costimulation

KW - IL-17

KW - NFATc1

KW - T cells

KW - c-Maf

UR - http://www.scopus.com/inward/record.url?scp=18144425185&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18144425185&partnerID=8YFLogxK

U2 - 10.1016/j.clim.2005.02.010

DO - 10.1016/j.clim.2005.02.010

M3 - Article

C2 - 15870016

AN - SCOPUS:18144425185

SN - 1521-6616

VL - 115

SP - 19

EP - 25

JO - Clinical Immunology

JF - Clinical Immunology

IS - 1 SPEC. ISS.

ER -

Regulation of immune and autoimmune responses by ICOS-B7h interaction

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this